Pioglitazone EP Impurity E CAS 868754-42-1
| CAS No. | 868754-42-1 |
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Pioglitazone EP Impurity E under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Pioglitazone EP Impurity E (CAS 868754-42-1, C20H25NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Pioglitazone EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 327.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Pioglitazone Standards
- Pioglitazone impurity 45 (CAS CATO-C4X-138345)
- Pioglitazone impurity 30 (CAS 1229114-66-2)
- Pioglitazone impurity 48 (CAS CATO-C4X-138348)
- Pioglitazone impurity 43 (CAS CATO-C4X-138343)
- Pioglitazone impurity 34 (CAS CATO-C4X-138334)
- Pioglitazone Impurity 22 (CAS CATO-C4X-138322)
- Pioglitazone impurity 42 (CAS CATO-C4X-138342)
- Pioglitazone Bromo Impurity (CAS 669716-58-9)
Recommended Standards
- Salbutamol EP Impurity G (CAS 64092-10-0)
- LCZ-696 Intermediate 39 (CAS 1426129-50-1)
- Salbutamol Impurity 123 (CAS CATO-C4X-1176123)
- LCZ-696 Impurity 66 (CAS 153037-40-2)
- Almotriptan Impurity 14 (CAS CATO-C4X-153814)
- Nintedanib Impurity 21 (CAS CATO-C4X-181421)
- Epinastine Impurity 52 (CAS 150399-28-3)
- 2-Bromo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-amine (CAS 1798792-42-3)
- Methyl 2-cyanothiophene-3-carboxylate (CAS 67808-30-4)
- 1-(2-Bromoethyl)-4-methylpiperazinedihydrobromide (CAS 801152-34-1)
- (S)-N-(1-(2-Aminoacetyl)pyrrolidin-3-yl)-N-cyclopropylacetamide (CAS 1354003-44-3)
- Tert-butyl ((1R,3R)-3-cyanocyclopentyl)carbamate (CAS 1417789-54-8)
- 4-(2-Isopropoxyethoxy)piperidine (CAS 70979-01-0)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com