Umeclidinium Impurity 4 CAS 869112-31-2
| CAS No. | 869112-31-2 |
| Molecular Formula | C22H28NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Umeclidinium Impurity 4 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Umeclidinium Impurity 4 (CAS 869112-31-2, C22H28NO2Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H28NO2Br, Umeclidinium Impurity 4 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 418.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Umeclidinium Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28NO2 Br |
| Molecular Weight | 418.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Umeclidinium Standards
- Umeclidinium Bromide Impurity 25 (CAS 119102-52-2)
- Umeclidinium impurity 26 (CAS 1248400-28-3)
- Umeclidinium Impurity 1 (CAS 1509910-91-1)
- Umeclidinium impurity 22 (CAS 17229-17-3)
- Umeclidinium Impurity 15 (CAS 2230024-91-4(free base))
- Umeclidinium Impurity 19 (CAS 2253743-32-5)
- Umeclidinium Impurity 13 (CAS 2253743-36-9)
- Umeclidinium Impurity 11 (CAS 2253743-38-1)
Recommended Standards
- Mirogabalin Impurity 110 (CAS CATO-C4X-2924110)
- Cefpodoxime Impurity 56 (CAS CATO-C4X-157956)
- Ambroxol Impurity 59 HCl (CAS 2664887-34-5)
- 1H-INDOLE, 5-BROMO-2,3-DIHYDRO- 22190-33-6 5-BROMO-2,3-DIHYDRO-1H-INDOLE 5-BROMOINDOLINE BC003236 (CAS 22190-33-6)
- Budesonide EP Impurity H (Mixture of Epimer) (CAS 313474-58-7)
- 2-(Methylsulfonyl)-7-(trifluoromethyl)-7,8-dihydroquinazolin-5(6H)-one (CAS 1420794-28-0)
- 6-(2,2-Difluoroethoxy)pyridine-2,3-diamine (CAS 1438251-11-6)
- (R)-1-(3-(trifluoromethoxy)phenyl)but-3-en-1-amine (CAS 1270119-24-8)
- 6-Chloroisoquinolin-1(2H)-one (CAS 131002-09-0)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
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