2-Chloro-4-hydroxynicotinonitrile CAS 869802-74-4
| CAS No. | 869802-74-4 |
| Molecular Formula | C6H3ClN2O |
| Molecular Weight | 154.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-4-hydroxynicotinonitrile (C6H3ClN2O) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-Chloro-4-hydroxynicotinonitrile (CAS 869802-74-4), molecular formula C6H3ClN2O and molecular weight 154.55 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-4-hydroxynicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN2O |
| Molecular Weight | 154.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-hydroxynicotinonitrile (CAS 1048913-62-7)
- 6-Chloro-5-hydroxynicotinonitrile (CAS 1187191-02-1)
- 3-Chloro-5-isocyanatopyridine (CAS 1260672-74-9)
- 3-Chloro-5-hydroxypicolinonitrile (CAS 1262860-70-7)
- 2-Chloro-5-hydroxyisonicotinonitrile (CAS 1445968-07-9)
- 2-Chloro-6-hydroxypyridine-4-carbonitrile (CAS 1556812-05-5)
- 4-Chloro-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 1611464-71-1)
- 5-Chloro-4-oxo-1,4-dihydropyridine-3-carbonitrile (CAS 1708250-63-8)
Recommended Standards
- 5-Chlorobenzofurazan (CAS 19155-86-3)
- 2-Chloro-4-isocyanatopyridine (CAS 855773-46-5)
- 6-Chloro-4-ethynylpyridazin-3(2H)-one (CAS 1866461-85-9)
- 2-Chloro-4-oxo-1,4-dihydropyridine-3-carbonitrile (CAS 727737-49-7)
- N-(2-(3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)ethyl)thiophene-2-carboxamide (CAS 1796988-94-7)
- 4-(ethoxy(phenyl)methyl)-1,1'-biphenyl (CAS 2137934-65-5)
- 2-Phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (CAS 7252-78-0)
- SIpOMeMesCuCl (CAS 2271064-72-1)
- (3S)-5-methyl-3-({[(3RS,4RS)-4-methylpyrrolidin-3-yl]formamido}methyl)hexanoic acid (CAS 1909293-59-9)
- 5-Iodo-1,4-dimethyl-1H-imidazole (CAS 1036991-39-5)
- N1-(1H-Benzo[d]imidazol-2-yl)ethane-1,2-diamine (CAS 34658-81-6)
- 2-(2-((Benzyl(methyl)amino)methyl)piperidin-1-yl)ethanol (CAS 1353944-13-4)
- VUF 11222 (CAS 1414376-84-3)
- Myristoyl Pentapeptide -4 acetate (CAS 959610-30-1(free base))
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