4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid CAS 870646-83-6
| CAS No. | 870646-83-6 |
| Molecular Formula | C12H19BF2O3Si |
| Molecular Weight | 288.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid (CAS 870646-83-6) is a high-purity analytical reference standard with the molecular formula C12H19BF2O3Si and a molecular weight of 288.17 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 4-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 288.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H19BF2O3Si |
| Molecular Weight | 288.17 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related t Standards
- 5-(t-Butyldimethylsilyloxy)-2,3-difluorophenylboronic acid (CAS 1150114-45-6)
- 3-(t-Butyldimethylsilyloxy)-4,5-difluorophenylboronic acid (CAS 2377609-56-6)
- 4-(t-Butyldimethylsilyloxy)-2,6-difluorophenylboronic acid (CAS 2096341-77-2)
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- 3-t-Butyldimethylsilyloxy-4-chlorophenylboronic acid (CAS 2096337-83-4)
- 1-(tert-butyldimethylsilyloxy)-2-iodoethane (CAS 101166-65-8)
- 6-Tert-Butyldimethylsilyloxy-4-(1-methylethenyl)-1-methyl-cyclohexane 1,2-epoxide (CAS 121289-19-8)
- 6-[[2-(tert-Butyldimethylsilyloxy)ethyl]methylamino]pyridin-3-ol (CAS 326496-02-0)
Recommended Standards
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- 2',3',4',5',6'-Pentafluoro[1,1'-biphenyl]-4-carboxylic acid (CAS 29779-01-9)
- Sertraline Impurity 66 (CAS CATO-C4X-134466)
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- N-(Triphenylmethyl)formamide (CAS 20799-66-0)
- Ethylcyclopentane (CAS 1640-89-7)
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- D-Nebivolol (SR,RR) HCl (CAS 213132-06-0)
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- 2,4,5-Trifluoro-3-methyl-6-nitrobenzoic acid (CAS 167887-95-8)
- Acetyl-Exenatide trifluoroacetate salt (CAS 305815-28-5)
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