3-Chloro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one CAS 87273-60-7
| CAS No. | 87273-60-7 |
| Molecular Formula | C9H7ClN2O2 |
| Molecular Weight | 210.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-Chloro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (C9H7ClN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
3-Chloro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 87273-60-7), molecular formula C9H7ClN2O2 and molecular weight 210.62 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7ClN2O2 |
| Molecular Weight | 210.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- Benzyl (2-fluoroethyl)carbamate (CAS 1862755-03-0)
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- 4-Amino-3-ethylbenzonitrile (CAS 170230-87-2)
- 6-Imino-1-methyl-1,6-dihydro-1,3,5-triazine-2,4-diamine (CAS 6291-82-3)
- N,N-Dimethylphosphoramidic Dichloride (CAS 677-43-0)
- 2-(4-Methoxyphenyl)pyrimidin-4(1H)-one (CAS 88627-13-8)
- 4-Bromo-5-cyano-2-methoxybenzoic acid (CAS 1805187-00-1)
- 3-Iodo-2,6-dimethylaniline hydrochloride (CAS 135630-62-5)
- 4-(4-Isopropyl-4H-1,2,4-triazol-3-yl)piperidine (CAS 1249273-72-0)
- Neuropeptide GE (CAS 134748-04-2)
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