Edaravone impurity 48 CAS 87343-64-4
| CAS No. | 87343-64-4 |
| Molecular Formula | C16H18N2O3 |
| Molecular Weight | 286.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Edaravone impurity 48 (CAS 87343-64-4), a pharmacopoeial impurity reference standard (molecular formula C16H18N2O3, MW 286.33 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Edaravone impurity 48 (C16H18N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18N2O3 |
| Molecular Weight | 286.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 2 |
Related Edaravone Standards
- Edaravone impurity 45 (CAS CATO-C4X-106245)
- Edaravone Impurity 56 (CAS CATO-C4X-106256)
- Edaravone Impurity 3 (CAS 1323485-71-7)
- Edaravone impurity 44 (CAS CATO-C4X-106244)
- Edaravone impurity 40 (CAS CATO-C4X-106240)
- Edaravone Impurity 33 (CAS 2762440-12-8)
- Edaravone Impurity 34 (CAS 2762440-11-7)
- Edaravone impurity 35 (Mixture of Enantiomers) (CAS CATO-C4X-106235)
Recommended Standards
- Mirabegron EP Impurity F (CAS 223673-34-5)
- Apixaban Impurity 148 (CAS CATO-C4X-1088148)
- Mirabegron Impurity 48 (CAS CATO-C4X-103248)
- Palbociclib Impurity 84 (CAS 571189-64-5)
- All-rac-alfa-Tocopherol EP Impurity C (Mixture of Isomers) (CAS CATO-C4X-119519)
- Fenticonazole EP Impurity D Nitrate (CAS 1313397-05-5)
- Letermovir Impurity 27 (CAS 2991059-71-1)
- Cyclohexylvalerate (CAS 1551-43-5)
- 4-Phenyl-3-(1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl)-5-(propylthio)-4H-1,2,4-triazole (CAS 477709-77-6)
- 26933-09-5 5,7-Dichloro-2-methylquinoline DTXSID20589084 (CAS 26933-09-5)
- 2-(3-Boronophenyl)acetic acid (CAS 914397-60-7)
- 2-Chloro-trans-zeatin (2CltZ) (CAS 29736-30-9)
- 1-(Bromomethyl)-5-fluoro-2-methyl-3-nitrobenzene (CAS 1378873-31-4)
- Semaglutide impurity 39 (CAS CATO-C4X-222639)
Why CATO?
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