tert-Butyl 2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate CAS 87378-58-3
| CAS No. | 87378-58-3 |
| Molecular Formula | C13H13F3N2O2 |
| Molecular Weight | 286.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 286.25 g/mol gives tert-Butyl 2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
tert-Butyl 2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate (CAS 87378-58-3) is a high-purity analytical reference standard with the molecular formula C13H13F3N2O2 and a molecular weight of 286.25 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, tert-Butyl 2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 286.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), tert-Butyl 2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13F3N2O2 |
| Molecular Weight | 286.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- N-Methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide (CAS 685531-31-1)
- Tert-butyl 2-cyano-2-[5-(trifluoromethyl)pyridin-2-yl]acetate (CAS 941133-76-2)
- N-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)pivalamide (CAS 478066-15-8)
- Clenbuterol-d9 (CAS 129138-58-5)
- 6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol (CAS 1807777-59-8)
- (R)-1-(4-(Benzyloxy)phenyl)ethan-1-ol (CAS 118239-25-1)
- Tert-butyl 5-fluoro-1-oxa-7-azaspiro[3.5]Nonane-7-carboxylate (CAS 2387176-80-7)
- 2,3-Dimethyl-1-[3-(methylsulfanyl)phenyl]-1,4-dihydropyridin-4-one (CAS 861210-59-5)
- 1-(2-(4-Bromo-2-chloro-3-methylphenoxy)ethyl)-4-methylpiperazine (CAS 2172820-44-7)
- (R)-3-Amino-4-(4-methoxyphenyl)butanoic acid hydrochloride (CAS 1421258-66-3)
- 2-(2-Bromophenyl)imidazo[1,2-a]pyridine (CAS 115769-03-4)
- N-(4-(Bromomethyl)phenyl)pivalamide (CAS 137105-37-4)
- trans-4,4-difluoro-2-(methoxycarbonyl)cyclopentane-1-carboxylic acid (CAS 1608143-73-2)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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