5-(Pyridin-1(2H)-yl)-2,6-bis(trifluoromethyl)pyrimidin-4(5H)-one CAS 87378-59-4
| CAS No. | 87378-59-4 |
| Molecular Formula | C11H7F6N3O |
| Molecular Weight | 311.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(Pyridin-1(2H)-yl)-2,6-bis(trifluoromethyl)pyrimidin-4(5H)-one (CAS 87378-59-4) is a high-purity analytical reference standard with the molecular formula C11H7F6N3O and a molecular weight of 311.18 g/mol.
The molecular framework of 5-(Pyridin-1(2H)-yl)-2,6-bis(trifluoromethyl)pyrimidin-4(5H)-one (C11H7F6N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-(Pyridin-1(2H)-yl)-2,6-bis(trifluoromethyl)pyrimidin-4(5H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H7F6N3O |
| Molecular Weight | 311.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Pyridin Standards
- 2-Methyl-5-(3-(pyridin-2-yl)-1H-1,2,4-triazol-5-yl)-4-(trifluoromethyl)thiazole (CAS 344262-30-2)
- 2-Methyl-5-(3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)-4-(trifluoromethyl)thiazole (CAS 344262-38-0)
- 2,4-Di(pyridin-2-yl)-6-(pyridin-3-yl)pyrimidine (CAS 2412116-10-8)
- 2,4-Di(pyridin-2-yl)-6-(pyridin-4-yl)pyrimidine (CAS 2412116-11-9)
- 2-((5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)-1-(p-tolyl)ethan-1-one (CAS 485334-76-7)
- 2-(Pyridin-2-ylsulfanyl)-N-[4-(1H-1,2,4-triazol-1-yl)phenyl]acetamide (CAS 763125-32-2)
- Methyl 4-(2-(pyridin-3-yl)benzyl)tetrahydro-2H-pyran-4-carboxylate (CAS 1361113-04-3)
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Recommended Standards
- 5-(4-Bromophenyl)-2,4'-bipyridine (CAS 859211-25-9)
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- 5-(4-Bromophenyl)-2,3'-bipyridine (CAS 917897-54-2)
- 5-Bromo-2,3-diphenylpyrazine (CAS 243472-70-0)
- 7-Chloroquinoline-8-sulfonamide (CAS 83055-70-3)
- (4-(((Tetrahydrofuran-2-yl)methyl)carbamoyl)phenyl)boronic acid (CAS 874534-61-9)
- (1R,2R)-2-Methylcyclopropanecarboxylic Acid (CAS 10487-86-2)
- 2-Amino-4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenol (CAS 1091990-97-4)
- Pyrrolidine-2,4-dicarboxylic acid (CAS 99319-03-6)
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- 2,7-Dibromo-9-heptyl-9H-carbazole (CAS 1173071-58-3)
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