1-(3-(Trifluoromethyl)pyridin-2-yl)piperazine hydrochloride CAS 87394-50-1
| CAS No. | 87394-50-1 |
| Molecular Formula | C10H12F3N3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
1-(3-(Trifluoromethyl)pyridin-2-yl)piperazine hydrochloride (CAS 87394-50-1) is a high-purity analytical reference standard with the molecular formula C10H12F3N3HCl and a molecular weight of 267.68 g/mol.
The molecular framework of 1-(3-(Trifluoromethyl)pyridin-2-yl)piperazine hydrochloride (C10H12F3N3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 1-(3-(Trifluoromethyl)pyridin-2-yl)piperazine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12F3N3 HCl |
| Molecular Weight | 267.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
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- (2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanol (CAS 1000339-72-9)
- methyl 3-((4-(trifluoromethyl)piperidin-1-yl)methyl)benzoate (CAS 1000339-86-5)
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- 3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)benzaldehyde (CAS 1000339-89-8)
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Recommended Standards
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- 5-((4-Fluorobenzyl)thio)-N-methyl-1,3,4-thiadiazol-2-amine (CAS 931046-37-6)
- 5'-(4-Carboxyphenyl)-2'-nitro-[1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid (CAS 1842393-52-5)
- Prednisolone impurity 68 (CAS CATO-C4X-173768)
- Tert-butyl (5-methoxy-4-(trimethylsilyl)pyridin-3-yl)carbamate (CAS 1045858-18-1)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
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