Thiocolchicoside Impurity 1 CAS 87424-25-7
| CAS No. | 87424-25-7 |
| Molecular Formula | C21H23NO5S |
| Molecular Weight | 401.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Thiocolchicoside Impurity 1 is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Thiocolchicoside Impurity 1 (CAS 87424-25-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H23NO5S and a molecular weight of 401.48 g/mol.
Thiocolchicoside Impurity 1 (C21H23NO5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Thiocolchicoside Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H23NO5S |
| Molecular Weight | 401.48 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Thiocolchicoside Standards
- Thiocolchicoside EP Impurity B (CAS 2730-71-4)
- Thiocolchicoside Impurity 3 (CAS 102419-91-0)
- Thiocolchicoside EP Impurity H (10-Demethoxy Colchicoside) (CAS CATO-C4X-27704)
- Thiocolchicoside EP Impurity G (CAS 177991-81-0)
- Thiocolchicoside EP Impurity E (CAS 219547-29-2)
- Thiocolchicoside EP Impurity K (CAS CATO-C4X-27703)
- Thiocolchicoside (CAS 602-41-5)
- Thiocolchicoside EP Impurity L (CAS CATO-C4X-27707)
Recommended Standards
- Daprodustat-D8 (CAS 2250290-94-7)
- methyl (2S)-2-[bis(tert-butoxycarbonyl)amino]-3-(4-hydroxyphenyl)propanoate (CAS 1187581-89-0)
- Cefodizime Impurity 3 (CAS 111298-82-9)
- Ethyl 4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido) pyrimidine-5-carboxylate-d6 (CAS 1189696-04-5)
- Ropivacaine Impurity 18 (CAS CATO-C4X-175318)
- Citalopram Impurity 68 (CAS 481047-48-7)
- Ampicillin Impurity 103 (CAS CATO-C4X-1443103)
- 4-([2,2'-Bithiophen]-5-yl)pyrimidin-2-amine (CAS 256239-01-7)
- (4-Fluoro-3-methylthiophen-2-yl)(phenyl)methanol (CAS 1250363-58-6)
- N-(4-Bromophenyl)-2-(4-ethyl-2,3-dioxopiperazin-1-yl)acetamide (CAS 868680-45-9)
- (R)-1-(2,6-dimethoxyphenyl)ethan-1-amine (CAS 1241682-75-6)
- Diethyl 1-amino-3-propyl-1H-pyrrole-2,4-dicarboxylate (CAS 310444-98-5)
- 6,7-Dichloro-2,4-bis(4-fluorophenyl)phthalazin-1(2H)-one (CAS 339009-77-7)
- Galanin (1-13)-Neuropeptide Y (25-36) amide (CAS 147138-51-0)
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