Sofosbuvir Impurity 4 CAS 874638-94-5
| CAS No. | 874638-94-5 |
| Molecular Formula | C31H26FN3O7 |
| Molecular Weight | 571.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sofosbuvir Impurity 4.
As a process- or degradation-related impurity, Sofosbuvir Impurity 4 (CAS 874638-94-5, C31H26FN3O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C31H26FN3O7, Sofosbuvir Impurity 4 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 571.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sofosbuvir Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C31H26FN3O7 |
| Molecular Weight | 571.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Sofosbuvir Standards
- Sofosbuvir Impurity 10 (CAS CATO-C4X-105210)
- Sofosbuvir Impurity 11 (CAS CATO-C4X-105211)
- Sofosbuvir Impurity 5 (CAS CATO-C4X-10525)
- Sofosbuvir Impurity 6 (CAS CATO-C4X-10526)
- Sofosbuvir Impurity 7 (CAS CATO-C4X-10527)
- Sofosbuvir Impurity 72 (CAS CATO-C4X-105272)
- Sofosbuvir Impurity 8 (CAS CATO-C4X-10528)
- Sofosbuvir Impurity 81 (CAS CATO-C4X-105281)
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