2-((6-Fluoroquinolin-4-yl)thio)acetic acid CAS 874766-46-8
| CAS No. | 874766-46-8 |
| Molecular Formula | C11H8FNO2S |
| Molecular Weight | 237.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-((6-Fluoroquinolin-4-yl)thio)acetic acid (CAS 874766-46-8), molecular formula C11H8FNO2S and molecular weight 237.25 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-((6-Fluoroquinolin-4-yl)thio)acetic acid (C11H8FNO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8FNO2S |
| Molecular Weight | 237.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Fluoroquinolin Standards
- 1-(7-Fluoroquinolin-8-yl)piperidin-4-one (CAS 917251-83-3)
- (1-((6-Fluoroquinolin-2-yl)methyl)pyrrolidin-2-yl)methanol (CAS 1221411-11-5)
- 4-((6-Fluoroquinolin-4-yl)amino)benzonitrile (CAS 1018045-41-4)
- 1-((6-Fluoroquinolin-8-yl)methyl)-3-methylpyridin-2(1h)-one (CAS 1333700-72-3)
- 2-(7-Fluoroquinolin-6-yl)acetic acid (CAS 1022091-54-8)
- 3-Acetyl-6-fluoroquinolin-4(1H)-one (CAS 1023293-18-6)
- 3-Acetyl-7-fluoroquinolin-4(1H)-one (CAS 1023293-76-6)
- 3-Acetyl-8-fluoroquinolin-4(1H)-one (CAS 1023294-06-5)
Recommended Standards
- 2-((3-Formylphenoxy)methyl)benzonitrile (CAS 928708-37-6)
- 2-([(Benzyloxy)carbonyl](ethyl)amino)acetic acid (CAS 70732-64-8)
- 1-Phenylquinoline-2,4(1h,3h)-dione (CAS 212517-39-0)
- 2-(1,3-Dioxooctahydro-2H-4,7-methanoisoindol-2-yl)propanoic acid (CAS 32392-58-8)
- N-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-2-amine, trifluoroacetic acid (CAS 1803592-44-0)
- 5a(H),17a(H),(20R)-3B-Acetoxyergost-8(14)-ene (CAS 4042-95-9)
- 4-[(carbamoylamino)methyl]benzoic acid (CAS 2372-49-8)
- (3-(Trifluoromethyl)pyrazin-2-yl)methanamine (CAS 1197235-85-0)
- (2E)-3-{[4-(4-chlorophenyl)-1H-pyrazol-5-yl]amino}-1-[5-(2,4-dichlorophenyl)furan-2-yl]prop-2-en-1-one (CAS 1037690-33-7)
- 2,2,2-Trifluoro-1-(4-fluoro-3-methylphenyl)ethanamine (CAS 886370-15-6)
- 3-Borono-5-hydroxybenzoic acid (CAS 851667-21-5)
- 2-Cyano-N-propylacetamide (CAS 52493-35-3)
- 3-((3,3,5-Trimethylcyclohexyl)amino)propan-1-ol (CAS 53444-00-1)
- C-Peptide 1 (rat) (CAS 41475-27-8)
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