Crizotinib Impurity 4 CAS 877399-50-3
| CAS No. | 877399-50-3 |
| Molecular Formula | C13H20BrN3O2 |
| Molecular Weight | 330.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Crizotinib Impurity 4.
As a process- or degradation-related impurity, Crizotinib Impurity 4 (CAS 877399-50-3, C13H20BrN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H20BrN3O2, Crizotinib Impurity 4 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 330.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Crizotinib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H20BrN3O2 |
| Molecular Weight | 330.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Crizotinib Standards
- Crizotinib Impurity 7 (CAS 877397-70-1)
- Crizotinib Impurity 8 (CAS 1233484-06-4)
- Crizotinib Impurity 54 (CAS CATO-C4X-102554)
- Crizotinib Impurity 46 (CAS CATO-C4X-102546)
- Crizotinib Impurity 11 (CAS 1448326-32-6)
- Crizotinib impurity 17 (CAS 2322541-37-5)
- Crizotinib Impurity 62 (CAS CATO-C4X-102562)
- Crizotinib Impurity 56 (CAS CATO-C4X-102556)
Recommended Standards
- tert-Butyl 3-bromo-6,6-dimethyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate (CAS 2089334-44-9)
- 4,4,5,5-Tetramethyl-2-(4-(naphthalen-1-yl)phenyl)-1,3,2-dioxaborolane (CAS 1028729-05-6)
- tert-Butyl 3-bromo-5,5-dimethyl-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate (CAS 2089320-48-7)
- 4,4,5,5-Tetramethyl-2-(2-(naphthalen-2-yl)phenyl)-1,3,2-dioxaborolane (CAS 1062555-59-2)
- Selexipag Impurity 16 (CAS CATO-C4X-196116)
- Phytomenadione/Vitamin K1 Impurity 129 (CAS 1181-23-3（无手性）)
- Furosemide Impurity 53 (CAS CATO-C4X-140253)
- 4-Bromo-N-ethyl-2-nitroaniline (CAS 56136-82-4)
- Dopamine Impurity 29 (CAS 15806-29-8)
- 4-Oxo-4,5,6,7-tetrahydro-2H-pyrrolo[3,4-c]pyridine-1-carbaldehyde (CAS 358732-55-5)
- 3-(2-Fluorobenzyl)quinoxalin-2(1H)-one (CAS 361189-43-7)
- 4-Acetyl-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (CAS 2386-30-3)
- 3-(3,4-Dichlorobenzyl)-1-ethyl-4-tosyl-1,3-dihydro-2H-imidazol-2-one (CAS 383148-73-0)
- Des-Ser39-Tirzepatide (CAS CATO-CPTD788936)
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