Crizotinib impurity 17 CAS 2322541-37-5
| CAS No. | 2322541-37-5 |
| Molecular Formula | C18H25N5O3 |
| Molecular Weight | 359.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Crizotinib impurity 17 (CAS 2322541-37-5, C18H25N5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H25N5O3, Crizotinib impurity 17 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 359.42 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H25N5O3 |
| Molecular Weight | 359.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib Impurity 56 (CAS CATO-C4X-102556)
- Crizotinib impurity 23 (CAS 877399-73-0)
- Crizotinib Impurity N12 (CAS 1401697-46-8)
- Crizotinib Impurity 2 (CAS 877399-74-1)
- Crizotinib impurity 14 (CAS CATO-C4X-102514)
- Crizotinib Impurity 3 (CAS 877399-00-3)
- Crizotinib impurity 36 (CAS CATO-C4X-102536)
- Crizotinib impurity 37 (CAS CATO-C4X-102537)
Recommended Standards
- Vonoprazan Impurity 101 (CAS 1885094-62-1)
- Tofacitinib Impurity 150 (CAS 1616761-01-3)
- tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperazine-1-carboxylate (CAS 227776-28-5)
- Tofacitinib Impurity 84 (CAS 1675248-18-6)
- Furan Impuirty 1 (5-Butoxy-3-Methyl-2(5H)-Furanone) (CAS 119054-21-6)
- Samidorphan impurity 1 (CAS 361525-83-9)
- Norepinephrine Impurity 66 HCl (CAS 62-22-6)
- Labetalol Impurity 52 (CAS CATO-C4X-246652)
- 2-(3,4,5-Trifluorophenyl)oxirane (CAS 253161-54-5)
- KB-R 7943 (CAS 182004-65-5)
- trans-tert-butyl (3R,4R)-3,4-diaminopyrrolidine-1-carboxylate (CAS 2173182-42-6)
- 2,2-Dimethylcyclopentane-1-sulfonamide (CAS 1538755-12-2)
- 1-(1-(2,2-Difluoroethyl)-1H-pyrazol-4-yl)-N-((1-propyl-1H-pyrazol-3-yl)methyl)methanamine hydrochloride (CAS 1856046-06-4)
- T-Peptide (CAS 2022956-62-1)
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