2-(3-Chlorothiophen-2-yl)acetonitrile CAS 880165-67-3
| CAS No. | 880165-67-3 |
| Molecular Formula | C6H4ClNS |
| Molecular Weight | 157.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(3-Chlorothiophen-2-yl)acetonitrile (C6H4ClNS) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-(3-Chlorothiophen-2-yl)acetonitrile (CAS 880165-67-3) is a high-purity analytical reference standard with the molecular formula C6H4ClNS and a molecular weight of 157.62 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClNS |
| Molecular Weight | 157.62 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorothiophen Standards
- 1-(5-Chlorothiophen-3-yl)propan-1-amine (CAS 1855722-36-9)
- 2-(4-Chlorothiophen-2-yl)acetaldehyde (CAS 1499659-20-9)
- 1-(2-Chlorothiophen-3-yl)ethan-1-one (CAS 81557-66-6)
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- 2-(5-Chlorothiophen-2-yl)acetaldehyde (CAS 853918-99-7)
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- (1S)-1-(5-Chlorothiophen-2-yl)ethan-1-amine (CAS 303070-26-0)
Recommended Standards
- 1-Chloro-N,N-dimethylmethanesulfonamide (CAS 35427-68-0)
- 2-(5-Chloro-2-thienyl)acetonitrile (CAS 42520-90-1)
- 5-(3-Chloroprop-1-yn-1-yl)-1,2-thiazole (CAS 1934769-99-9)
- 3-Chloro-5-methylthiophene-2-carbonitrile (CAS 2119577-82-9)
- 1-Ketoaethiopinone (CAS 105062-36-0)
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- Oleyl Alcohol (CAS 143-28-2)
- 4,5-Dihydro-2H-spiro[furan-3,3'-indoline] (CAS 1618672-05-1)
- (R)-N-(2,6-Dichlorobenzyl)pyrrolidin-3-amine hydrochloride (CAS 1289585-44-9)
- (3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one (CAS 86204-17-3)
- (2-(((5-Chloro-1,2,3-thiadiazol-4-yl)methyl)thio)-1-methyl-1H-imidazol-5-yl)methanol (CAS 338422-47-2)
- [a-Glu](Side chain transposition)- Semaglutide (CAS CATO-C4X-2226111)
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