(2R,3R,4R,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-ol CAS 881881-89-6
| CAS No. | 881881-89-6 |
| Molecular Formula | C11H13ClFN5O3 |
| Molecular Weight | 317.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (2R,3R,4R,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-ol (CAS 881881-89-6), a certified reference material (molecular formula C11H13ClFN5O3, MW 317.70 g/mol) for analytical method development and quality control.
(2R,3R,4R,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-ol (C11H13ClFN5O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H13ClFN5O3 |
| Molecular Weight | 317.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Recommended Standards
- (2R,3S,4S,5R)-2-(2-Chloro-6-(methylamino)-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 122654-31-3)
- 1-Chloro-4-(4-fluoro-2-nitrophenoxy)naphthalene (CAS 477859-01-1)
- Efavirenz Impurity 6 (CAS 1627575-36-3)
- 4-Chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide (CAS 865285-29-6)
- 3-Hydroxy-1-methylazetidine (CAS 111043-48-2)
- 4-Bromo-7-ethoxy-1H-indole-2-carboxylic acid (CAS 1098340-08-9)
- (E)-Cyano(methoxyimino)-acetic Acid (CAS 57336-69-3)
- 1-amino-3-(propan-2-yl)-2,3-dihydro-1H-indene-1-carboxylic acid (CAS 1803591-59-4)
- N-(3-(methylamino)propyl)cyclobutanecarboxamide (CAS 1153998-15-2)
- 4-Isopropyl-N,N-dimethylpyrimidin-2-amine (CAS 180283-89-0)
- 3-(3-Ethylphenoxy)pyrrolidine hydrochloride (CAS 946681-79-4)
- 1-(4-Chlorophenyl)-2,5-dimethyl-1h-pyrrole-3-carboxylic acid (CAS 60217-76-7)
- 8-Methoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid (CAS 247225-89-4)
- Des-Pro36-Tirzepatide (CAS CATO-CPTD788937)
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