Efavirenz Impurity 6 CAS 1627575-36-3
| CAS No. | 1627575-36-3 |
| Molecular Formula | C14H11ClF3NO2 |
| Molecular Weight | 317.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Efavirenz Impurity 6 (C14H11ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Efavirenz Impurity 6 (CAS 1627575-36-3, C14H11ClF3NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Efavirenz Impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H11ClF3NO2 |
| Molecular Weight | 317.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz USP Related Compound B (CAS 440124-96-9)
- Efavirenz Impurity 3 (CAS 205755-86-8)
- Efavirenz 2-Desoxo-2-methly (CAS 1258498-53-1)
- rac Efavirenz-d4 (CAS 1246812-58-7)
- Efavirenz (CAS 154598-52-4)
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 2 (CAS 154801-74-8)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
Recommended Standards
- (2R,3S,4S,5R)-2-(2-Chloro-6-(methylamino)-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 122654-31-3)
- (2R,3R,4R,5R)-5-(2-Amino-6-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-ol (CAS 881881-89-6)
- Metflurazon (CAS 23576-23-0)
- 1-Chloro-4-(4-fluoro-2-nitrophenoxy)naphthalene (CAS 477859-01-1)
- Latamoxef Impurity 15 (CAS CATO-C4X-179815)
- Neratinib Impurity 30 (CAS CATO-C4X-113430)
- Dabigatran Impurity 68 (CAS 103041-38-9)
- (R)-1-(5-Bromopyridin-3-yl)ethan-1-ol (CAS 1027256-80-9)
- Ethyl 2-bromo-3-cyano-4-nitrobenzoate (CAS 1807029-79-3)
- 2-Amino-2-(4,6-dimethylpyrimidin-2-yl)acetic acid (CAS 1218151-90-6)
- N-(3,5-Difluorophenyl)-4-methylbenzenesulfonamide (CAS 838893-89-3)
- 4-Oxo-3,4,7,8-tetrahydro-6H-pyrrolo[2,1-c][1,4]thiazine-1-carbonitrile 2,2-dioxide (CAS 1325304-56-0)
- tert-Butyl (2-hydroxy-1-methoxyethyl)carbamate (CAS 113525-88-5)
- Glucagon receptor antagonist I (CAS 438618-32-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com