4-Chloro-2-(4-chlorophenyl)-6-fluoroquinazoline CAS 885277-63-4
| CAS No. | 885277-63-4 |
| Molecular Formula | C14H7Cl2FN2 |
| Molecular Weight | 293.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-2-(4-chlorophenyl)-6-fluoroquinazoline (CAS 885277-63-4) is a high-purity analytical reference standard with the molecular formula C14H7Cl2FN2 and a molecular weight of 293.12 g/mol.
Based on its molecular formula C14H7Cl2FN2, 4-Chloro-2-(4-chlorophenyl)-6-fluoroquinazoline contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 293.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-(4-chlorophenyl)-6-fluoroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H7Cl2FN2 |
| Molecular Weight | 293.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-2-(4-chlorophenyl)-7-fluoroquinazoline (CAS 885277-75-8)
- 4-Chloro-3-chlorosulfonyl-benzenesulfonyl fluoride (CAS 79005-54-2)
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- 6-Chloro-2-(4-chlorophenyl)-1-methoxy-1H-benzo[d]imidazole (CAS 338978-89-5)
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Recommended Standards
- 4-Bromo-N-(4-nitrophenyl)benzenamine (CAS 40932-71-6)
- 4,7-Dichloro-2-(4-fluoro-phenyl)-quinazoline (CAS 885277-41-8)
- 4,7-Dichloro-2-(2-fluorophenyl)quinazoline (CAS 885277-55-4)
- 5-Bromo-2-nitro-N-phenylaniline (CAS 6311-47-3)
- 6-Chloro-1-(3,4-dimethoxyphenyl)hexan-1-one (CAS 19347-74-1)
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-[2-[(2-hydroxybenzoyl)amino]ethyl] Ester (CAS 92565-34-9)
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- 4-chlorobenzyl 2-[2-(2,3,3-trichloroacryloyl)hydrazino]-4-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 648859-35-2)
- 80134-83-4 L-(1-~13~C,~15~N)Leucine DTXSID20583966 (CAS 80134-83-4)
- 2-(Pyrimidin-2-yl)isoindolin-1-imine hydrobromide (CAS 1171549-94-2)
- 7-Chloro-2-(3,4-dichlorophenyl)-4H-benzo[d][1,3]oxazin-4-one (CAS 332033-38-2)
- Atrasentan Impurity 176 (CAS 1059051-99-8)
- Q-Peptide trifluoroacetate salt (CAS 1361235-89-3)
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