Axitinib Impurity N28 CAS 886230-75-7
| CAS No. | 886230-75-7 |
| Molecular Formula | C19H18N4O3 |
| Molecular Weight | 350.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Axitinib Impurity N28 (CAS 886230-75-7), a pharmacopoeial impurity reference standard (molecular formula C19H18N4O3, MW 350.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C19H18N4O3, Axitinib Impurity N28 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 350.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Axitinib Impurity N28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18N4O3 |
| Molecular Weight | 350.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 4 |
Related Axitinib Standards
- Axitinib Impurity 18 (CAS CATO-C4X-107118)
- Axitinib Impurity 71 (CAS CATO-C4X-107171)
- Axitinib Impurity 55 (CAS CATO-C4X-107155)
- Axitinib Impurity 77 (CAS CATO-C4X-107177)
- Axitinib Impurity 48 (CAS 1959572-98-5)
- Axitinib Impurity 15 (CAS CATO-C4X-107115)
- Axitinib Impurity 14 (CAS CATO-C4X-107114)
- Axitinib Impurity N3 (CAS 885520-24-1)
Recommended Standards
- 8-Hydrazinyl-1,3-dimethyl-7-(naphthalen-1-ylmethyl)-3,7-dihydro-1h-purine-2,6-dione (CAS 476480-41-8)
- Bis(Isopropyl) Ester (CAS 35717-98-7)
- 5-{[4-(Benzyloxy)phenyl]methylene}-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (CAS 321657-70-9)
- Ethyl 2-(5-methyl-3-phenylisoxazole-4-carboxamido)benzoate (CAS 544457-76-3)
- Promethazine EP Impurity C (R-Isomer) (CAS CATO-C3D-262692)
- Tenofovir alafenamide Impurity 51 (CAS 2126010-02-2(Free Base))
- Difamilast Impurity 7 (CAS 1574285-43-0)
- n-(Tert-butyl)-2-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)acetamide (CAS 1210896-54-0)
- 2-(2,6-dichlorophenyl)propan-2-amine hydrochloride (CAS 1240528-65-7)
- methyl 5-(trifluoromethyl)pyrazine-2-carboxylate (CAS 1346252-26-3)
- 1-chloro-3-methylbutan-2-ol (CAS 55033-10-8)
- Ethyl 4,5-diaminopicolinate (CAS 1000783-11-8)
- 2-(Difluoromethoxy)-4-methoxybenzaldehyde (CAS 1247613-99-5)
- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com