Axitinib Impurity N3 CAS 885520-24-1
| CAS No. | 885520-24-1 |
| Molecular Formula | C7H4I2N2 |
| Molecular Weight | 369.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrile group, iodine substitution, an aromatic ring system, Axitinib Impurity N3 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 369.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Axitinib Impurity N3 (CAS 885520-24-1, C7H4I2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Axitinib Impurity N3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4I2N2 |
| Molecular Weight | 369.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Related Axitinib Standards
- Axitinib Impurity 38 (CAS 319472-78-1)
- Axitinib Impurity 58 (CAS 3037703-03-7)
- Axitinib Impurity 14 (CAS CATO-C4X-107114)
- Axitinib Impurity 41 (CAS 319462-41-4)
- Axitinib Acid (CAS 319462-34-5)
- Axitinib Impurity 55 (CAS CATO-C4X-107155)
- Axitinib Impurity 77 (CAS CATO-C4X-107177)
- Axitinib Impurity 74 (CAS CATO-C4X-107174)
Recommended Standards
- 3,5-Diiodo-1H-indazole (CAS 351456-48-9)
- 2-chloroacetic acid [3-[(2-methylanilino)-oxomethyl]-2-naphthalenyl] ester 35245-26-2 A822672 [3-[(2-methylphenyl)carbamoyl]naphthalen-2-yl] 2-chloranylethanoate (CAS 35245-26-2)
- 3,4-Diiodo-1H-indazole (CAS 885518-66-1)
- 1,3-Diiodoimidazo[1,5-a]pyridine (CAS 2046954-44-1)
- Verteporfin Impurity 7 (CAS CATO-C4X-35497)
- Palbociclib Impurity 209 (CAS CATO-C4X-1125209)
- Demeclocycline EP Impurity F (CAS CATO-C4X-16086)
- N-Boc-alpha-methylpiperidine-4-methanamine (CAS 863560-23-0)
- Quinoxaline (CAS CATO-C3D-5812)
- 3-Quinolinecarboxylic acid, 6,8-dibromo-4-chloro-, ethyl ester (CAS 1275545-13-5)
- 2,2-Difluoropropanamide (CAS 49781-48-8)
- 4-Cyclopropoxy-N,N-dimethyl-3-nitroaniline (CAS 1243345-64-3)
- 4-(4,5-Dimethyl-1,3-dioxolan-2-yl)-2-methoxyphenol (CAS 63253-24-7)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
Why CATO?
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