3-Chloro-5-fluoro-4-methoxybenzyl alcohol CAS 886497-33-2
| CAS No. | 886497-33-2 |
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Chloro-5-fluoro-4-methoxybenzyl alcohol (CAS 886497-33-2), molecular formula C8H8ClFO2 and molecular weight 190.60 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-5-fluoro-4-methoxybenzyl alcohol (C8H8ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 3-Chloro-5-fluoro-4-methoxybenzyl alcohol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-4-ethoxy-5-fluorophenol (CAS 1017778-82-3)
- 2-Chloro-4-ethyl-5-fluoro-6-methoxypyrimidine (CAS 1192479-51-8)
- (5-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1266177-72-3)
- 5-Chloro-3-fluoro-2-(2-hydroxyethylamino)pyridine (CAS 1280786-67-5)
- 4-Chloro-2-fluoro-3-methoxybenzyl alcohol (CAS 1323966-21-7)
- (R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol, 97% (CAS 1453854-84-6)
- 1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol (CAS 1558116-77-0)
- (3-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1616601-81-0)
Recommended Standards
- 3-Chloro-4-ethoxy-2-fluorophenol (CAS 909122-52-7)
- 5-Chloro-α-oxo-2-thiopheneacetic acid (CAS 56479-07-3)
- 2-Chloro-6-fluoro-3-methoxybenzyl alcohol (CAS 886499-49-6)
- 6-Chloro-2-fluoro-3-methoxybenzyl alcohol (CAS 886499-68-9)
- 2-(Chloromethyl)-5-cyclopropyl-1,3,4-oxadiazole (CAS 915924-77-5)
- 4-Methoxy-N-(propan-2-yl)aniline hydrochloride (CAS 1240529-20-7)
- 1-(Cyclopropylmethyl)-1-ethylguanidine (CAS 1411673-05-6)
- 2,2,5,5-Tetramethyl-3-amino-pyrrolidine-1-oxyl Free Radical (CAS 34272-83-8)
- 4-Ethoxy-3,5-difluorobenzoic acid (CAS 1017779-19-9)
- Tretinoin Impurity 24 (CAS CATO-C4X-196924)
- N-(3-(5-Bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (CAS 1262985-24-9)
- 3-Fluoroquinoline-4-carboxylic acid (CAS 153880-32-1)
- 7-Methoxy-2-(trifluoromethyl)benzo[d]thiazole (CAS 1188025-84-4)
- Tirzepatide Impurity 57 (CAS CATO-C4X-324057)
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