(3S,5R)-Atorvastatin EP Impurity B (single configuration) Calcium salt CAS 887196-25-0
| CAS No. | 887196-25-0 |
| Molecular Formula | 2*C33H34FN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(3S,5R)-Atorvastatin EP Impurity B (single configuration) Calcium salt (CAS 887196-25-0) is a certified pharmaceutical impurity reference standard with the molecular formula C33H34FN2O5Ca and a molecular weight of 597.72 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, (3S,5R)-Atorvastatin EP Impurity B (single configuration) Calcium salt is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 597.72 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | 2*C33H34FN2O5 Ca |
| Molecular Weight | 597.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
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- 2-(Phenoxymethyl)pyrimidine-4-carbaldehyde (CAS 1131605-22-5)
- 2-(Dimethylamino)-6-methylpyrimidin-4(3H)-one (CAS 19810-73-2)
- 8-Methyl-2-phenyl-4-(p-tolyl)thiochromane (CAS 681443-36-7)
- [(1-Chloro-2,3-dimethylcyclopropyl)thio]benzene (CAS 64474-33-5)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
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