Ethyl 2-amino-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxylate CAS 887267-76-7
| CAS No. | 887267-76-7 |
| Molecular Formula | C12H10F2N2O2S |
| Molecular Weight | 284.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 2-amino-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxylate (C12H10F2N2O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Ethyl 2-amino-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxylate (CAS 887267-76-7) is a high-purity analytical reference standard with the molecular formula C12H10F2N2O2S and a molecular weight of 284.28 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Ethyl 2-amino-4-(2,5-difluorophenyl)-1,3-thiazole-5-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10F2N2O2S |
| Molecular Weight | 284.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Ethyl 2-amino-4-(3,5-difluorophenyl)thiazole-5-carboxylate (CAS 1188151-91-8)
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- 5-((6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)amino)-5-oxopentanoic acid (CAS 109418-98-6)
- (S)-2-amino-7-methyl-4-(5-methylfuran-2-yl)-5-oxo-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile (CAS 351449-17-7)
- 4-Amino-1-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-1,3,5-triazin-2(1H)-one (CAS 686300-58-3)
- 4-Amino-1-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one (CAS 65370-90-3)
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Recommended Standards
- 7-(1H-benzo[d]imidazol-2-yl)-1,1,1-trifluoroheptan-2-one (CAS 240121-55-5)
- Ethyl 5-((tert-butoxycarbonyl)amino)-2-fluoroisonicotinate (CAS 2089319-61-7)
- 6-Fluoro-3-(4-methoxyphenyl)-4-methylcoumarin (CAS 527751-33-3)
- n-(4-Aminophenyl)-3,4-difluorobenzenesulfonamide (CAS 793679-09-1)
- (4-Chlorophenyl)pentafluoro-lambda6-sulfane (CAS 5310-68-9)
- Tert-butyl (R)-(1-methylpyrrolidin-3-yl)carbamate (CAS 346691-01-8)
- 3-(Oxetan-3-yl)pyrrolidine (CAS 1273567-00-2)
- (R)-2-Amino-3-(thiazol-5-yl)propanoic acid (CAS 1431881-52-5)
- 4-(3-fluorophenyl)butan-2-amine (CAS 1092924-64-5)
- 4-hydroxypyridazine-3-carboxylic acid (CAS 1246668-88-1)
- Methyl 5-(hydroxymethyl)-4-methoxypicolinate (CAS 1263058-74-7)
- tert-Butyl (2-(2-(4-(2-(2-aminoethoxy)ethyl)piperazin-1-yl)ethoxy)ethyl)carbamate (CAS 2357110-42-8)
- Pioglitazone Impurity 8 (CAS 74772-78-4)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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