Methyl 4-chloro-6,8-difluoroquinoline-2-carboxylate CAS 887589-39-1
| CAS No. | 887589-39-1 |
| Molecular Formula | C11H6ClF2NO2 |
| Molecular Weight | 257.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 4-chloro-6,8-difluoroquinoline-2-carboxylate.
Methyl 4-chloro-6,8-difluoroquinoline-2-carboxylate (CAS 887589-39-1) is a high-purity analytical reference standard with the molecular formula C11H6ClF2NO2 and a molecular weight of 257.62 g/mol.
The molecular framework of Methyl 4-chloro-6,8-difluoroquinoline-2-carboxylate (C11H6ClF2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H6ClF2NO2 |
| Molecular Weight | 257.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 4-Chloro-6-(2,4-difluorophenoxy)pyrimidin-5-amine (CAS 1193217-94-5)
- Methyl 4-chloro-5,8-difluoroquinoline-2-carboxylate (CAS 219949-93-6)
- 1-(6-Chloro-3-nitropyridin-2-yl)azetidine-3-carboxylic acid (CAS 866151-10-2)
- 2-Chloro-5-(2-ethoxy-1,1,2,2-tetrafluoroethyl)pyridine (CAS 2138526-11-9)
- 3-(2-Chloro-5-nitropyrimidin-4-yl)pentane-2,4-dione (CAS 97821-68-6)
- 6-Chloro-8-nitro-3,4-dihydro-2h-1-benzopyran-3-carboxylic acid (CAS 926239-75-0)
- 7-Chloro-8-(2-hydroxyethoxy)pyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione (CAS 2883421-73-4)
- Ethyl 4-Chloro-7-oxo-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine-6-carboxylate (CAS 66751-59-5)
Recommended Standards
- Methyl 3-(2-chloroethyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylate (CAS 113960-08-0)
- 7,8-Difluoro-2-methoxyquinoline-4-carbonyl chloride (CAS 1125702-48-8)
- 5-(2-Chloroacetamido)benzene-1,3-dicarboxylic acid (CAS 61389-11-5)
- Bis(pentyloxy)titanium(III) chloride (CAS 97158-24-2)
- 2-Cyclopropoxy-N,N-dimethyl-3-(methylsulfonamido)benzamide (CAS 1243320-21-9)
- 4-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)aniline (CAS 1204296-33-2)
- 2,5-Dichloro-4-iodopyridine (CAS 796851-03-1)
- N,N-dimethyl-3-((methylamino)methyl)benzamide hydrochloride (CAS 1216127-06-8)
- 2-((3-Chlorophenoxy)methyl)morpholine (CAS 167273-59-8)
- N-(5-Methyl-1,3,4-thiadiazol-2-yl)-2-((6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-2-yl)thio)acetamide (CAS 899948-61-9)
- 2-Hydrazino-nicotinonitrile (CAS 368869-92-5)
- 1,5-Dimethyl-1H-indazole (CAS 70127-93-4)
- 4-Chloro-2-cyclobutylthieno[2,3-d]pyrimidine (CAS 1478737-15-3)
- Des-Pro36-37-Tirzepatide (CAS CATO-CPTD788938)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com