7-Bromo-2-(tert-butyl)-4-chloroquinazoline CAS 887592-23-6
| CAS No. | 887592-23-6 |
| Molecular Formula | C12H12BrClN2 |
| Molecular Weight | 299.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Bromo-2-(tert-butyl)-4-chloroquinazoline (CAS 887592-23-6), molecular formula C12H12BrClN2 and molecular weight 299.59 g/mol, is a CATO reference standard with documented purity and traceability.
7-Bromo-2-(tert-butyl)-4-chloroquinazoline (C12H12BrClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12BrClN2 |
| Molecular Weight | 299.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 6-Bromo-1-chloro-2-isopropoxynaphthalene (CAS 1394291-46-3)
- 6-Bromo-2-(tert-butyl)-4-chloroquinazoline (CAS 887592-20-3)
- 2-bromo-5-ethoxybenzene-1-sulfonyl chloride (CAS 1019115-70-8)
- 3-Bromo-4-ethoxybenzene-1-sulfonyl chloride (CAS 1093065-10-1)
- 4-Bromo-2-(4-chlorobenzyl)-1-fluorobenzene (CAS 1210344-21-0)
- 5-Bromo-2-chloro-n-ethylpyridine-3-sulfonamide (CAS 1247490-86-3)
- (3-Bromo-4-methoxyphenyl)methanesulfonyl chloride (CAS 1250721-89-1)
- 1-Bromo-4-(chloro(4-fluorophenyl)methyl)benzene (CAS 1340421-97-7)
Recommended Standards
- N-(3-Bromopropyl)-7-chloroquinolin-4-amine (CAS 60548-23-4)
- 4-Chloro-2,6-bis(trifluoromethyl)quinoline (CAS 91991-79-6)
- 98591-57-2 7-Chloro-4-iodoquinoline DTXSID20458100 (CAS 98591-57-2)
- 4-Chloro-2,8-bis(trifluoromethyl)quinoline (CAS 83012-13-9)
- 2-(6-Chloro-5-(difluoromethyl)-4-fluoropyridin-3-yl)acetic acid (CAS 1805263-06-2)
- 1-Chloro-4-(1-iodoethyl)benzene (CAS 495405-71-5)
- 1-Benzyl-6-hydroxy-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydropyrimidine-4-carboxamide (CAS 338412-62-7)
- 2,3,3',4,5'-Pentabromodiphenyl Ether (CAS 446254-71-3)
- 5-Chloro-3-(4-methoxy-phenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (CAS 1448694-38-9)
- 1-(3,4-Dimethoxyphenyl)-2-methylpropan-2-ol (CAS 23037-61-8)
- 5α-Cholestan-3α,7α,12α-triol (CAS 16669-19-5)
- 6-(Bromomethyl)-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole (CAS 1824342-98-4)
- 3-(3-Benzyl-1,2,4-oxadiazol-5-yl)propan-1-amine hydrochloride (CAS 1374408-39-5)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
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