6-(2,4-Difluorophenyl)picolinic acid CAS 887983-05-3
| CAS No. | 887983-05-3 |
| Molecular Formula | C12H7F2NO2 |
| Molecular Weight | 235.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6-(2,4-Difluorophenyl)picolinic acid (CAS 887983-05-3) is a high-purity analytical reference standard with the molecular formula C12H7F2NO2 and a molecular weight of 235.19 g/mol.
The molecular framework of 6-(2,4-Difluorophenyl)picolinic acid (C12H7F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H7F2NO2 |
| Molecular Weight | 235.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 6-(3,5-Difluorophenyl)-nicotinic acid (CAS 1033844-89-1)
- 5-(3,5-Difluorophenyl)nicotinic acid (CAS 1048267-36-2)
- 5-(3,4-Difluorophenyl)nicotinic acid (CAS 1048486-16-3)
- 5-(3,4-Difluorophenyl)-picolinic acid (CAS 1225477-53-1)
- 2-(3,5-Difluorophenyl)nicotinic acid (CAS 1225477-61-1)
- 2-(3,5-Difluorophenyl)isonicotinic acid (CAS 1225477-70-2)
- 2-(3,4-Difluorophenyl)isonicotinic acid (CAS 1225511-01-2)
- 2-(3,4-Difluorophenyl)nicotinic acid (CAS 1225511-07-8)
Recommended Standards
- 6-(2,4-Difluorophenyl)nicotinic acid (CAS 505082-74-6)
- 6-(2,5-Difluorophenyl)nicotinic acid (CAS 887976-55-8)
- 6-(2,3-Difluorophenyl)picolinic acid (CAS 887983-10-0)
- 6-(2,5-Difluorophenyl)picolinic acid (CAS 887983-00-8)
- 3-Carbamoyl-4-carboxy-1,2,5-oxadiazole 2-oxide (CAS 204335-82-0)
- 5-((4-Iodo-1H-pyrazol-1-yl)methyl)-3-methylisoxazole (CAS 1342774-34-8)
- 1-(1,5-Dihydrobenzo[e][1,3]dioxepin-3-yl)-N-(furan-2-ylmethyl)methanamine (CAS 374913-99-2)
- [2-(Butylthio)ethyl]amine hydrochloride (CAS 3492-83-9)
- 4-Chloro-6-cyclohexylpyrimidin-2(1h)-imine (CAS 688782-65-2)
- 2-(1H-1,3-Benzodiazol-2-yl)-4-chloro-5-(morpholin-4-yl)-2,3-dihydropyridazin-3-one (CAS 565192-21-4)
- 2,2,2-Trifluoro-1-(1,2,3,4-tetrahydronaphthalen-1-yl)ethan-1-one (CAS 1343362-69-5)
- Tricarbonyltris(triphenylphosphine)ruthenium (CAS 151757-44-7)
- 2-(Bromomethyl)benzenemethanol 2-(Bromomethyl)benzyl alcohol 2-Hydroxymethylbenzylbromide 74785-02-7 (CAS 74785-02-7)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com