Dotinurad Impurity 123 CAS 888731-24-6
| CAS No. | 888731-24-6 |
| Molecular Formula | C15H11Cl2NO2 |
| Molecular Weight | 308.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dotinurad Impurity 123.
As a process- or degradation-related impurity, Dotinurad Impurity 123 (CAS 888731-24-6, C15H11Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dotinurad Impurity 123 (C15H11Cl2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 308.16 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dotinurad Impurity 123 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11Cl2NO2 |
| Molecular Weight | 308.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dotinurad Standards
- Dotinurad Impurity 229 (CAS CATO-C4X-2494229)
- Dotinurad Impurity 184 (CAS CATO-C4X-2494184)
- Dotinurad Impurity 140 (CAS CATO-C4X-2494140)
- Dotinurad Impurity 48 (CAS CATO-C4X-249448)
- Dotinurad Impurity 44 (CAS CATO-C4X-249444)
- Dotinurad Impurity 90 (CAS CATO-C4X-249490)
- Dotinurad Impurity 255 (CAS CATO-C4X-2494255)
- Dotinurad Impurity 50 (CAS CATO-C4X-249450)
Recommended Standards
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- 2-Bromo-N-(1,3,5-trimethyl-1h-pyrazol-4-yl)benzamide (CAS 1007007-62-6)
- Pranoprofen Impurity 41 (CAS CATO-C4X-181141)
- n-(4-Bromo-3-methylphenyl)-2,5-dimethylfuran-3-carboxamide (CAS 1016847-22-5)
- Indocyanine Green Impurity 52 (CAS CATO-C4X-250352)
- Oseltamivir Impurity 57 HCI (CAS CATO-C4X-1720248)
- Natamycin Impurity 10 (CAS CATO-C4X-204010)
- 1-(3,5-Dibromo-2-hydroxyphenyl)ethanone (CAS 22362-66-9)
- 3-Formyl-1-benzothiophene-2-carboxylic acid (CAS 22120-80-5)
- 4-Chloro-2-ethyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one (CAS 2172931-40-5)
- 3-Bromo-5-(trifluoromethyl)quinoline (CAS 2177257-71-3)
- Methyl 3-amino-5-fluoro-2-hydroxybenzoate (CAS 1175529-01-7)
- 2,6-Dimethoxybenzaldehyde oxime (CAS 174966-94-0)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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