3-(2-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine CAS 890635-53-7
| CAS No. | 890635-53-7 |
| Molecular Formula | C19H14ClFN4 |
| Molecular Weight | 352.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(2-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine.
CATO supplies 3-(2-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine (CAS 890635-53-7), a certified reference material (molecular formula C19H14ClFN4, MW 352.79 g/mol) for analytical method development and quality control.
The molecular framework of 3-(2-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine (C19H14ClFN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(2-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H14ClFN4 |
| Molecular Weight | 352.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chlorophenyl Standards
- 2-((4-Chlorophenyl)thio)-N-(2-methoxy-5-nitrophenyl)acetamide (CAS 461399-66-6)
- 3-(3-Chlorophenyl)-5-((2,6-difluorobenzyl)thio)-4H-1,2,4-triazol-4-amine (CAS 578698-20-1)
- 3-(4-Chlorophenyl)-5-((2,6-difluorobenzyl)thio)-4H-1,2,4-triazol-4-amine (CAS 577790-80-8)
- 3-(4-Chlorophenyl)-6-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine (CAS 439107-57-0)
- 4-[2-(4-Chlorophenyl)acetyl]-8-methyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326808-38-1)
- 3-(((4-Chlorophenyl)imino)methyl)-2-hydroxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinolin-4-one (CAS 338953-30-3)
- 4-[3-(4-Chlorophenyl)-4,5,6,7-tetrahydro-2H-indazol-2-yl]benzoic acid (CAS 861210-33-5)
- N-(4-chlorophenyl)-1,4,9-trioxa-12-azadispiro[4.2.4(8).2(5)]Tetradecane-12-carboxamide (CAS 861209-91-8)
Recommended Standards
- 2-((1-Cyanocyclohexyl)amino)-2-oxoethyl 2-(2-chloro-6-fluorophenyl)acetate (CAS 877831-41-9)
- 1-[(2-Chloro-6-fluorophenyl)methoxy]-2-phenyl-1H-1,3-benzodiazole (CAS 338791-17-6)
- 1-(Benzo[d][1,3]dioxol-5-yl)-3-((4-chlorophenyl)sulfonyl)propan-1-one (CAS 868256-03-5)
- 3-Iodothiophene-2-carboxylic acid (CAS 676995-91-8)
- 1-(3,5-Bis(trifluoromethyl)phenyl)piperazine (CAS 16172-96-6)
- 2-Ethoxy-4,6-dimethylpyrimidin-5-amine (CAS 1706439-09-9)
- tert-Butyl 2-azaspiro[4.4]non-7-ene-2-carboxylate (CAS 1638761-14-4)
- 5-(3,4-Dimethylphenyl)oxazole-2(3H)-thione (CAS 950272-74-9)
- n-Methyl-1-(piperidin-3-yl)methanesulfonamide (CAS 1247670-75-2)
- cis-2-(4-Thiomethylbenzoyl)cyclopentane-1-carboxylic acid (CAS 1134326-38-7)
- 3-(Methoxycarbonyl)-1,1-dimethylpiperidin-1-ium bromide (CAS 60296-01-7)
- 2-(tert-Butylcarbamoyl)-5-methoxyphenylboronic acid (CAS 2096333-56-9)
- 4-methyl-2-(4H-1,2,4-triazol-3-yl)-1,3-thiazole-5-carboxylic acid (CAS 1258651-75-0)
- Peptide Impurity 27 (CAS 1350456-68-6)
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