6-Fluoro-2,3-dihydroxynaphthalene-1,4-dione CAS 89226-84-6
| CAS No. | 89226-84-6 |
| Molecular Formula | C10H5FO4 |
| Molecular Weight | 208.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Fluoro-2,3-dihydroxynaphthalene-1,4-dione.
6-Fluoro-2,3-dihydroxynaphthalene-1,4-dione (CAS 89226-84-6), molecular formula C10H5FO4 and molecular weight 208.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Fluoro-2,3-dihydroxynaphthalene-1,4-dione (C10H5FO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5FO4 |
| Molecular Weight | 208.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F-containing |
Related Fluoro Standards
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- 5-Fluoro-2-oxo-2H-chromene-3-carboxylic acid (CAS 1540476-86-5)
- 6-Fluoro-2-oxo-2h-chromene-3-carboxylic acid (CAS 937688-27-2)
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Recommended Standards
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- 3,3,4,4,5,5,6,6,6-Nonafluorohex-1-en-1-yl carbonate (CAS 1469980-27-5)
- 4-Bromo-2-methyloxazolo[4,5-c]pyridine (CAS 1935133-71-3)
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