4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline CAS 892414-55-0
| CAS No. | 892414-55-0 |
| Molecular Formula | C20H21ClF5N3O2Si |
| Molecular Weight | 493.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline (CAS 892414-55-0), a certified reference material (molecular formula C20H21ClF5N3O2Si, MW 493.93 g/mol) for analytical method development and quality control.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-((6-Chloro-3-(trifluoromethyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)-3,5-difluoroaniline is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 493.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21ClF5N3O2Si |
| Molecular Weight | 493.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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- 3-(2-Chloro-6-fluorophenyl)-N-(2-hydroxy-5-(piperidin-1-ylsulfonyl)phenyl)-5-methylisoxazole-4-carboxamide (CAS 748146-36-3)
- N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((5-((4-fluorobenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 477333-35-0)
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- 2-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-5-[(2,4-diphenyl-1,3-thiazol-5-yl)methyl]-1,3,4-oxadiazole (CAS 338750-03-1)
- N-(2-Chloro-4,6-dimethylphenyl)-2-((4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618432-50-1)
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Recommended Standards
- 1-Tetratriacontanamine (CAS 66214-29-7)
- N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-((4-chlorophenyl)sulfonyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 895646-86-3)
- 4,6-Dibromo-2-(3-iodophenyl)benzo[d]oxazol-5-amine (CAS 586996-09-0)
- 4,6-Dibromo-2-(3-iodophenyl)-2H-benzo[d][1,2,3]triazol-5-amine (CAS 1706437-39-9)
- (4-((Methoxyimino)methyl)phenyl)boronic acid (CAS 393820-31-0)
- 3-(Butylamino)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5(4H)-one (CAS 195511-48-9)
- (R)-5-Fluoro-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 1931934-94-9)
- Pyrrolidine, 2-methyl-5-phenyl- (CAS 1357391-22-0)
- Cyclopropyl 2,3-dimethylphenyl ketone (CAS 898790-00-6)
- Cefazolin Impurity 26 (CAS CATO-C4X-157726)
- 2-(5-Oxo-7-pivaloyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-6-yl)acetic acid (CAS 1269534-74-8)
- (3-Chloro-4-methoxyphenyl)hydrazine (CAS 24630-85-1)
- 1-(1H-Benzo[d]imidazol-2-yl)-4-benzyl-3-methyl-1H-pyrazol-5-ol (CAS 1006582-11-1)
- Cholecystokinin, CCK Tetrapeptide (30-33) (CAS 35144-91-3)
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