5-(3-(Trifluoromethyl)phenyl)thiophene-2-carboxylic acid CAS 893733-18-1
| CAS No. | 893733-18-1 |
| Molecular Formula | C12H7F3O2S |
| Molecular Weight | 272.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(3-(Trifluoromethyl)phenyl)thiophene-2-carboxylic acid is closely related to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(3-(Trifluoromethyl)phenyl)thiophene-2-carboxylic acid (CAS 893733-18-1) is a high-purity analytical reference standard with the molecular formula C12H7F3O2S and a molecular weight of 272.24 g/mol.
Based on its molecular formula C12H7F3O2S, 5-(3-(Trifluoromethyl)phenyl)thiophene-2-carboxylic acid contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 272.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-(3-(Trifluoromethyl)phenyl)thiophene-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7F3O2S |
| Molecular Weight | 272.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 4-Phenyl-5-(trifluoromethyl)thiophene-2-carboxylic acid (CAS 208108-76-3)
- 2-((3-(Trifluoromethyl)phenyl)amino)thiazole-4-carbaldehyde (CAS 126533-84-4)
- 1-(5-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine (CAS 1708268-21-6)
- (R)-3-(Trifluoromethyl)-7,8,9,10-tetrahydro-5H-pyrazino[1,2-a]pyrido[3,2-e]pyrazin-6(6aH)-one (CAS 2817667-47-1)
- 1-[3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazine (CAS 338748-56-4)
- 3-(Trifluoromethyl)-7,8,9,10-tetrahydro-5H-pyrazino[1,2-a]pyrido[3,2-e]pyrazin-6(6aH)-one (CAS 2820001-13-4)
- N-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)isobutyramide (CAS 478066-14-7)
- 3-methyl-1-[4-(trifluoromethyl)phenyl]hexahydropyrimidine-2,4-dione (CAS 101394-18-7)
Recommended Standards
- 5-(3-(Trifluoromethoxy)phenyl)thiophene-2-carbaldehyde (CAS 887987-48-6)
- 5-(t-Butyldimethylsilyloxymethyl)thiophen-3-boronic acid (CAS 2122282-85-1)
- 5-(2-(Trifluoromethoxy)phenyl)thiophene-2-carbaldehyde (CAS 675596-29-9)
- Diethyl 2-(2,5-difluorophenyl)malonate (CAS 247170-23-6)
- 2-Chloro-4-methyl-6-(pyrrolidin-1-yl)pyrimidine (CAS 425425-25-8)
- Methyl ethanecarboximidate (CAS 20258-22-4)
- (4S,4′S)-2,2′-(1-Methylethylidene)bis[4,5-dihydro-4-methyl-4-phenyloxazole] (CAS 869304-96-1)
- 2-Methyl-5-(4-(methylsulfonyl)phenyl)-4-phenylpyridazin-3(2H)-one (CAS 213763-80-5)
- 8-methylnaphthalene-1-carboxylic acid (CAS 19310-98-6)
- Ethyl 1-amino-2-ethyl-4-methyl-1H-pyrrole-3-carboxylate (CAS 77588-66-0)
- 5-(Hydroxymethyl-d2)uracil-6-d1 (CAS 352438-73-4)
- 3-Ethyl-4-phenylfuran-2-carbohydrazide (CAS 576169-70-5)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl pivalate (CAS 894770-94-6)
- Gastric Inhibitory Polypeptide (1-30) amide (porcine) (CAS 134846-93-8)
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