Bempedoic Acid Impurity 38 CAS 89541-21-9
| CAS No. | 89541-21-9 |
| Molecular Formula | C13H23BrO4 |
| Molecular Weight | 323.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Bempedoic Acid Impurity 38 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Bempedoic Acid Impurity 38 (CAS 89541-21-9, C13H23BrO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bempedoic Acid Impurity 38 (C13H23BrO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H23BrO4 |
| Molecular Weight | 323.22 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Br-containing |
Related Bempedoic Standards
- Bempedoic Acid Impurity 51 (CAS 2127387-65-7)
- Bempedoic Acid Impurity 10 (CAS CATO-C4X-218910)
- Bempedoic Acid Impurity 27 (CAS 738606-42-3)
- Bempedoic Acid Impurity 26 (CAS CATO-C4X-218926)
- Bempedoic Acid Impurity 9 (CAS CATO-C4X-21899)
- Bempedoic Acid Intermediate Impurity 14 (CAS 413624-71-2)
- Bempedoic Acid (CAS 738606-46-7)
- Bempedoic Acid Impurity 30 (CAS CATO-C4X-218930)
Recommended Standards
- n-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide (CAS 914610-50-7)
- 5-Bromo-7-((diethylamino)methyl)-2-methylquinolin-8-ol (CAS 113712-96-2)
- N-Cyclopropyl-2-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide (CAS 2377607-54-8)
- tert-Butyl (5-bromo-3-methoxypyridin-2-yl)methylcarbamate (CAS 1138443-96-5)
- Selumetinib Impurity 7 (CAS CATO-C4X-30537)
- Tolvaptan Impurity 71 (CAS CATO-C4X-195571)
- Palbociclib Impurity 69 (CAS 6163-63-9)
- N-(Benzo[d][1,3]dioxol-5-yl)-2-(methylthio)nicotinamide (CAS 796115-52-1)
- 1-(4-Bromo-1,3-thiazol-2-yl)-1h-1,2,4-triazole (CAS 1500213-20-6)
- 3-(5-Bromo-2-methoxyphenyl)-2-hydroxypropanoic acid (CAS 1466822-23-0)
- Atropine Impurity 35 (CAS 5928-44-9)
- 2-Chloro-5-(difluoromethyl)-3-methyl-4-nitropyridine (CAS 1805268-50-1)
- 2-Bromo-5-nitropyridine (CAS 4487-59-6)
- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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