Selumetinib Impurity 7 CAS CATO-C4X-30537
| CAS No. | CATO-C4X-30537 |
| Molecular Formula | C16H18F2N6O4 |
| Molecular Weight | 396.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Selumetinib Impurity 7 (CAS CATO-C4X-30537, C16H18F2N6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Selumetinib Impurity 7 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 396.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Selumetinib Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18F2N6O4 |
| Molecular Weight | 396.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Selumetinib Standards
- Selumetinib Impurity 6 (CAS CATO-C4X-30536)
- Selumetinib Impurity 20 (CAS CATO-C4X-305320)
- Selumetinib Impurity 12 (CAS CATO-C4X-305312)
- Selumetinib Impurity 8 (CAS CATO-C4X-30538)
- Selumetinib Impurity 21 (CAS CATO-C4X-305321)
- Selumetinib Impurity N1 (CAS 606144-02-9)
- Selumetinib Impurity 1 (CAS CATO-C4X-30531)
- Selumetinib (CAS 606143-52-6)
Recommended Standards
- Vericiguat Impurity 67 (CAS 2755814-39-0)
- Talazoparib Impurity 5 (CAS CATO-C4X-33735)
- Doxorubicin Impurity 36 (CAS CATO-C4X-203336)
- 5,5'-Dithiobis(2-nitrobenzoic Acid) (CAS 69-78-3)
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Isoprenaline Impurity 22 HCl (CAS 721917-88-0(free base))
- Paliperidone Impurity 76 (CAS CATO-C4X-172476)
- 20-Methoxy-20-oxoicosanoic acid (CAS 1767-98-2)
- 2-(Furan-3-yl)benzoic acid (CAS 1340107-48-3)
- 6-(2-Methylbut-3-en-2-yl)-7H-furo[3,2-g]chromen-7-one (CAS 13164-03-9)
- 7-Bromo-1-methyl-4-nitro-[1,2,4]triazolo[4,3-a]quinoline (CAS 1300031-89-3)
- 4-(5-Fluoroquinoline-8-sulfonamido)benzoic acid (CAS 1628431-07-1)
- 3-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)phenol (CAS 850640-17-4)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
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