1-(2-Chloroacetyl)pyrimidine-2,4(1H,3H)-dione CAS 89581-68-0
| CAS No. | 89581-68-0 |
| Molecular Formula | C6H5ClN2O3 |
| Molecular Weight | 188.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 188.57 g/mol gives 1-(2-Chloroacetyl)pyrimidine-2,4(1H,3H)-dione distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-(2-Chloroacetyl)pyrimidine-2,4(1H,3H)-dione (CAS 89581-68-0) is a high-purity analytical reference standard with the molecular formula C6H5ClN2O3 and a molecular weight of 188.57 g/mol.
The molecular framework of 1-(2-Chloroacetyl)pyrimidine-2,4(1H,3H)-dione (C6H5ClN2O3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-(2-Chloroacetyl)pyrimidine-2,4(1H,3H)-dione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H5ClN2O3 |
| Molecular Weight | 188.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloroacetyl Standards
- 5-(2-chloroacetyl)furan-3-carboxylic acid (CAS 1251924-13-6)
- 4-(2-Chloroacetyl)-1,3-dimethyl-1H-pyrazol-5(4H)-one (CAS 185746-06-9)
- N-(Chloroacetyl)-3-fluoroaniline (CAS 350-81-2)
- 5-(2-Chloroacetyl)furan-3-carboxamide (CAS 1251923-22-4)
- n-(2-Chloroacetyl)furan-2-carboxamide (CAS 878466-49-0)
- 4-(2-Chloroacetyl)-5,5-dimethyl-4,5-dihydro-3H-1,2,4-triazol-3-one (CAS 130138-03-3)
- 1-(2-Chloroacetyl)piperidine-4-carbonitrile (CAS 1003320-12-4)
- N-(2-chloroacetyl)-1H-pyrrole-2-carboxamide (CAS 1000931-83-8)
Recommended Standards
- (6-Chloro-5-nitropyridin-3-yl)methanol (CAS 321845-12-9)
- 1-Methyl-4-nitro-1H-pyrrole-2-carbonyl chloride (CAS 28494-51-1)
- 6-Chloro-2-methyl-4-nitropyridin-3-ol (CAS 1956369-78-0)
- 2-Amino-4-chloro-5-nitrophenol (CAS 6358-07-2)
- 2-(Difluoromethyl)-3-fluorophenol (CAS 1214333-85-3)
- 2-((4-Ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-sulfamoylphenyl)acetamide (CAS 565446-72-2)
- (R)-1-(5-(tert-Butyl)-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (CAS 808756-71-0)
- 6,7-Dimethyl-1H-benzo[d]imidazol-5-amine (CAS 946932-54-3)
- (1-Benzyloxycarbonylimino-2,2,2-trifluoro-ethyl)-phosphonic acid diethyl ester (CAS 296238-72-7)
- Methyl 2-(pyrimidin-5-yl)propanoate (CAS 1250731-02-2)
- (4-Iodophenyl)(5-methylpyridin-2-yl)methanone (CAS 1187163-47-8)
- 1-methylpyrrolidine-2-carbaldehyde (CAS 13493-88-4)
- (S)-4-(tert-Butoxycarbonyl)-3-methylmorpholine-3-carboxylic acid (CAS 1638744-49-6)
- Sperm Activating Peptide, Sea Urchin (CAS 140653-27-6)
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