Toremifene impurity 5 CAS 89778-23-4
| CAS No. | 89778-23-4 |
| Molecular Formula | C26H29NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Toremifene impurity 5 (CAS 89778-23-4, C26H29NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Toremifene impurity 5 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 423.98 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C26H29NO2 HCl |
| Molecular Weight | 423.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Toremifene Standards
- Toremifene N-Oxide (CAS 163130-29-8)
- Toremifene Impurity 3 (CAS 1798421-30-3)
- Toremifene impurity 7 (CAS 604010-60-8)
- Toremifene impurity 01 (CAS 89778-26-7)
- Toremifene (CAS 89778-27-8)
- Toremifene impurity 8 (CAS 89778-29-0)
- Toremifene impurity 9 Citrate (CAS 89778-29-0 (free base))
- (E)-Toremifene HCl (CAS 89778-29-0(free base))
Recommended Standards
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- 5-(Dimethylamino)pentan-1-ol (CAS 27384-58-3)
- 1-(2-(Octylamino)-1H-imidazol-4-yl)ethanone (CAS 88723-18-6)
- N-((1-Isopropyl-5-methyl-1H-pyrazol-4-yl)methyl)-3-morpholinopropan-1-amine dihydrochloride (CAS 1856079-23-6)
- 1-Benzyl-N-(4-methoxyphenyl)-1H-benzo[d]imidazol-2-amine (CAS 160060-70-8)
- (Z)-benzofuran-2-carbohydrazonamide (CAS 72583-89-2)
- 3-(Methoxycarbonyl)-2H-cyclohepta[b]furan-2-one (CAS 50603-71-9)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
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