(2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-(trifluoromethyl)phenyl)methanone CAS 898756-33-7
| CAS No. | 898756-33-7 |
| Molecular Formula | C22H22F3NO3 |
| Molecular Weight | 405.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-(trifluoromethyl)phenyl)methanone is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-(trifluoromethyl)phenyl)methanone (CAS 898756-33-7) is a high-purity analytical reference standard with the molecular formula C22H22F3NO3 and a molecular weight of 405.41 g/mol.
(2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-(trifluoromethyl)phenyl)methanone (C22H22F3NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22F3NO3 |
| Molecular Weight | 405.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Dioxa Standards
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-(trifluoromethyl)phenyl)methanone (CAS 898756-27-9)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-(trifluoromethyl)phenyl)methanone (CAS 898756-30-4)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-(trifluoromethyl)phenyl)methanone (CAS 898762-03-3)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-(trifluoromethyl)phenyl)methanone (CAS 898762-05-5)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-(trifluoromethyl)phenyl)methanone (CAS 898762-07-7)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-(trifluoromethyl)phenyl)methanone (CAS 898758-10-6)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(3-(trifluoromethyl)phenyl)methanone (CAS 898758-12-8)
- (4-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(4-(trifluoromethyl)phenyl)methanone (CAS 898758-14-0)
Recommended Standards
- ((3aR,4R,6R,6aR)-2,2-Dimethyl-6-(2-oxo-4-(1H-1,2,4-triazol-1-yl)pyrimidin-1(2H)-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate (CAS 2346620-54-8)
- Methyl 2-((7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinate (CAS 1956371-58-6)
- N-(4-(1-(2-(4,5-Dihydro-1H-imidazol-2-yl)hydrazono)ethyl)phenyl)-7-nitro-1H-indole-2-carboxamide (CAS 1093793-10-2)
- Taltirelin (CAS 103300-74-9)
- 4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-bromonicotinic acid (CAS 2243511-76-2)
- 1-Heptyl-1H-benzo[d][1,2,3]triazole (CAS 131164-34-6)
- O-Benzyl Xamoterol (CAS 69630-21-3)
- 3-[3-(2-Oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazol-4-yl]-acrylic acid (CAS 301676-60-8)
- (3,4-Dichlorophenyl)(thiazol-2-yl)methanone (CAS 1039167-75-3)
- 1-(2,3-Dihydrobenzofuran-3-yl)ethan-1-amine (CAS 1423025-50-6)
- (R)-2-(4-chloro-2,3,6-trifluorophenyl)pyrrolidine (CAS 1241679-69-5)
- [4-(3-cyclopropyl-1H-pyrazol-1-yl)phenyl]methanamine hydrochloride (CAS 1803585-91-2)
- (S)-5-Chloro-2-(pyrrolidin-2-yl)-1H-benzo[d]imidazole (CAS 944030-64-2)
- Semaglutide Impurity 3 (CAS CATO-C4X-22263)
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