1-(3-Chloro-5-fluorophenyl)-3-(4-fluorophenyl)propan-1-one CAS 898768-64-4
| CAS No. | 898768-64-4 |
| Molecular Formula | C15H11ClF2O |
| Molecular Weight | 280.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(3-Chloro-5-fluorophenyl)-3-(4-fluorophenyl)propan-1-one (CAS 898768-64-4) is a high-purity analytical reference standard with the molecular formula C15H11ClF2O and a molecular weight of 280.70 g/mol.
The molecular framework of 1-(3-Chloro-5-fluorophenyl)-3-(4-fluorophenyl)propan-1-one (C15H11ClF2O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11ClF2O |
| Molecular Weight | 280.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- Ethyl 3-(6-chloro-2-oxo-2H-chromen-3-yl)propanoate (CAS 1365939-25-8)
- 1-(2-Chloro-4-fluorophenyl)-3-(3-fluorophenyl)propan-1-one (CAS 898767-50-5)
- 1-(3-Chloro-4-fluorophenyl)-3-(3-fluorophenyl)propan-1-one (CAS 898767-29-8)
- 1-(4-Chloro-2-fluorophenyl)-3-(3-fluorophenyl)propan-1-one (CAS 898767-55-0)
- 1-(4-Chloro-3-fluorophenyl)-3-(4-fluorophenyl)propan-1-one (CAS 898768-46-2)
- 2-Chloro-4-fluoro-3-(4-fluorophenyl)propiophenone (CAS 898768-62-2)
- 3-(3-Chloro-5-fluorophenyl)-1-(2-fluorophenyl)propan-1-one (CAS 898750-94-2)
- 3-(3-Chloro-5-fluorophenyl)-3-fluoropropiophenone (CAS 898750-58-8)
Recommended Standards
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- 3-(3-Chloro-5-fluorophenyl)-4-fluoropropiophenone (CAS 898750-61-3)
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