(3,4-Difluorophenyl)(thiophen-3-yl)methanone CAS 898771-62-5
| CAS No. | 898771-62-5 |
| Molecular Formula | C11H6F2OS |
| Molecular Weight | 224.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(3,4-Difluorophenyl)(thiophen-3-yl)methanone (CAS 898771-62-5) is a high-purity analytical reference standard with the molecular formula C11H6F2OS and a molecular weight of 224.23 g/mol.
The molecular framework of (3,4-Difluorophenyl)(thiophen-3-yl)methanone (C11H6F2OS) is characterized by sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H6F2OS |
| Molecular Weight | 224.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluorophenyl Standards
- (3,5-Difluorophenyl)(thiophen-3-yl)methanone (CAS 898771-64-7)
- 5-(2,3-Difluorophenyl)thiophene-2-carbaldehyde (CAS 887987-08-8)
- 5-(2,4-Difluorophenyl)thiophene-2-carbaldehyde (CAS 887986-73-4)
- 2-(2,4-Difluorophenyl)-1-(4H-1,2,4-triazol-3-yl)ethan-1-amine (CAS 1490975-40-0)
- 2-(3,4-Difluorophenyl)cycloheptan-1-one (CAS 1341752-75-7)
- (3,4-Difluorophenyl)(5-methylfuran-2-yl)methanol (CAS 1250381-15-7)
- (3,5-Difluorophenyl)(5-methylfuran-2-yl)methanol (CAS 1343189-28-5)
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Recommended Standards
- (2-Fluoro-5-methylpyridin-3-yl)(morpholino)methanone (CAS 2404733-78-2)
- (1S,2S)-rel-2-(4-Ethoxy-3-fluorophenyl)cyclopropane-1-carboxylic acid (CAS 2055840-75-8)
- (3-Amino-4-fluorophenyl)(morpholin-4-yl)methanone (CAS 959795-65-4)
- (1R,2R)-rel-2-(3-Ethoxy-4-fluorophenyl)cyclopropane-1-carboxylic acid (CAS 2055841-05-7)
- 7-fluoro-1-methyl-indazol-6-amine (CAS 1896804-52-6)
- tert-Butyl (trans-4-((4-methylpyrimidin-2-yl)amino)cyclohexyl)carbamate (CAS 1289388-52-8)
- 4-Oxopiperidine-3-carbonitrile Hydrochloride (CAS 1373253-28-1)
- Troxipide Impurity 8 (CAS CATO-C4X-21488)
- N-(3-Fluorophenyl)-5-methyl-11-oxo-5H,5aH,6H,7H,8H,9H,11H-pyrido[2,1-b]quinazoline-3-carboxamide (CAS 1574583-66-6)
- Cyclopropyl(thiophen-3-yl)methanone (CAS 113348-25-7)
- 4,4-Di-n-propylcyclohexanone (CAS 123018-62-2)
- 2C-I-NBOMe 4-Methoxy HCl (CAS 1566571-64-9)
- 2-Acetamido-3-(7-fluoro-1H-indol-3-yl)propanoic acid (CAS 138471-57-5)
- Antiarrhythmic peptide (cattle atrium) (CAS 81771-37-1)
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