3-(1,3-Dioxan-2-yl)-2-trifluoromethylpropiophenone CAS 898786-55-5
| CAS No. | 898786-55-5 |
| Molecular Formula | C14H15F3O3 |
| Molecular Weight | 288.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
3-(1,3-Dioxan-2-yl)-2-trifluoromethylpropiophenone (CAS 898786-55-5), molecular formula C14H15F3O3 and molecular weight 288.26 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(1,3-Dioxan-2-yl)-2-trifluoromethylpropiophenone is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 288.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H15F3O3 |
| Molecular Weight | 288.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Dioxan Standards
- 1-(2-(2-(1,3-Dioxan-2-yl)ethyl)phenyl)-2,2,2-trifluoroethan-1-one (CAS 886370-24-7)
- 3-(1,3-Dioxan-2-yl)-1-(3-(trifluoromethyl)phenyl)propan-1-one (CAS 898786-57-7)
- 3-(1,3-Dioxan-2-yl)-4-trifluoromethylpropiophenone (CAS 898786-59-9)
- (R)-1-(2-(2-(1,3-Dioxan-2-yl)ethyl)phenyl)-2,2,2-trifluoroethan-1-amine (CAS 1228557-65-0)
- (S)-1-(2-(2-(1,3-Dioxan-2-yl)ethyl)phenyl)-2,2,2-trifluoroethan-1-amine (CAS 1228561-23-6)
- 884504-34-1 3-(1,3-Dioxan-2-yl)-1-(4-pentylphenyl)propan-1-one DTXSID20645977 (CAS 884504-34-1)
- 5-(4-(1,3-Dioxan-2-yl)-3-fluorophenyl)-2-chloropyridine (CAS 1206969-79-0)
- Ethyl 3-(1,3-dioxan-2-yl)-4-fluorobenzoylformate (CAS 951888-37-2)
Recommended Standards
- 2-Hydroxy-n-(4-methoxy-2-nitrophenyl)benzamide (CAS 73454-95-2)
- 3,3,3-(2,4,6-Trioxo-1,3,5-triazinane-1,3,5-triyl)tripropanenitrile (CAS 2904-28-1)
- 2-Hydroxy-n-(2-methoxy-4-nitrophenyl)benzamide (CAS 73454-94-1)
- 3-Ethoxy-4-((5-nitropyridin-2-yl)oxy)benzaldehyde (CAS 702646-74-0)
- 6-Amino-2-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione (CAS 10495-37-1)
- tert-Butyl 2-cyanospiro[chroman-4,4'-piperidine]-1'-carboxylate (CAS 1378979-76-0)
- CPF4, PDE-FRET-Sensor (CAS 407578-87-4)
- tert-butyl 2-(2-chloroacetamido)acetate (CAS 500309-13-7)
- 2-(4-(Tert-butoxycarbonyl)piperazin-1-yl)-2-methylpropanoic acid hydrochloride (CAS 1427380-01-5)
- Phenacetin Impurity 8 (CAS 188905-67-1)
- 3-Bromo-2-fluoro-4-iodoaniline (CAS 2092868-71-6)
- 2-Cyclopropoxy-6-fluorobenzaldehyde (CAS 1243351-49-6)
- 4,8-Dimethyl-2-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,6,2-dioxazaborocane (CAS 1536530-95-6)
- Semaglutide impurity 32 (CAS CATO-C4X-222632)
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