Phenacetin Impurity 8 CAS 188905-67-1
| CAS No. | 188905-67-1 |
| Molecular Formula | C14H13ClN2O |
| Molecular Weight | 260.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Phenacetin Impurity 8 (CAS 188905-67-1) is a certified pharmaceutical impurity reference standard with the molecular formula C14H13ClN2O and a molecular weight of 260.72 g/mol.
Structurally, Phenacetin Impurity 8 (C14H13ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 260.72 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H13ClN2O |
| Molecular Weight | 260.72 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Phenacetin Standards
- Phenacetin Impurity 12 (CAS 21650-66-8)
- Phenacetin Impurity 13 (CAS 71297-93-3)
- Phenacetin Impurity 2 (CAS 614-26-6)
- Phenacetin Impurity 9 (CAS 588-52-3)
- Phenacetin Impurity N1 (CAS 21650-51-1)
- Phenacetin Impurity 16 (CAS 30926-04-6)
- Phenacetin Impurity 10 (CAS 15596-57-3)
- Phenacetin Impurity 7 (CAS 60457-49-0)
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