3-Chloro-5-fluoro-3-(2-methylphenyl)propiophenone CAS 898789-88-3
| CAS No. | 898789-88-3 |
| Molecular Formula | C16H14ClFO |
| Molecular Weight | 276.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-5-fluoro-3-(2-methylphenyl)propiophenone (CAS 898789-88-3), molecular formula C16H14ClFO and molecular weight 276.73 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-5-fluoro-3-(2-methylphenyl)propiophenone (C16H14ClFO) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14ClFO |
| Molecular Weight | 276.73 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-(2-Chloro-4-fluorophenyl)-3-(o-tolyl)propan-1-one (CAS 898789-85-0)
- 1-(3-Chloro-4-fluorophenyl)-3-(m-tolyl)propan-1-one (CAS 898790-93-7)
- 1-(4-Chloro-3-fluorophenyl)-3-(m-tolyl)propan-1-one (CAS 898790-90-4)
- 1-(4-Chloro-3-fluorophenyl)-3-(p-tolyl)propan-1-one (CAS 898768-91-7)
- 2-Chloro-4-fluoro-3-(3-methylphenyl)propiophenone (CAS 898791-14-5)
- 3-(3-Chloro-5-fluorophenyl)-1-(m-tolyl)propan-1-one (CAS 898750-07-7)
- 3-(3-Chloro-5-fluorophenyl)-1-(p-tolyl)propan-1-one (CAS 898750-10-2)
- 3-Chloro-4-fluoro-3-(2-methylphenyl)propiophenone (CAS 898789-66-7)
Recommended Standards
- 3-Chloro-4-fluoro-3-(4-methylphenyl)propiophenone (CAS 898768-93-9)
- 3-Chloro-5-fluoro-3-(3-methylphenyl)propiophenone (CAS 898791-17-8)
- 3-Chloro-5-fluoro-3-(4-methylphenyl)propiophenone (CAS 898769-13-6)
- 4-(Chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene (CAS 957205-24-2)
- 4-Chloro-1-hydroxynaphthalene-2-carbaldehyde (CAS 58132-06-2)
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