2-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione CAS 908129-24-8
| CAS No. | 908129-24-8 |
| Molecular Formula | C8H10FN3O5 |
| Molecular Weight | 247.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione (CAS 908129-24-8) is a high-purity analytical reference standard with the molecular formula C8H10FN3O5 and a molecular weight of 247.18 g/mol.
The molecular framework of 2-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione (C8H10FN3O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H10FN3O5 |
| Molecular Weight | 247.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- 1-Bromo-3-fluoro-2-(trimethylsilyl)benzene (CAS 632324-41-5)
- 2-((3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)amino)ethan-1-ol (CAS 309741-26-2)
- (2S,3S,4S,5S)-2-(Fluoromethyl)-5-(2-nitro-1H-imidazol-1-yl)tetrahydrofuran-3,4-diol (CAS 220793-03-3)
- 2-Nitro-4-sulfobenzoic acid (CAS 552-23-8)
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- Dichloro-oxacalix[2]arene[2]triazine, 95% (CAS 819065-56-0)
- 4-(Formamidomethyl)benzene-1-sulfonyl fluoride (CAS 56862-46-5)
- 2-(2-Chloro-3-pyridyl)acetonitrile (CAS 101012-32-2)
- 5-Propylthiazole-4-carboxylic acid (CAS 900587-93-1)
- tert-Butyl 4-(5-((chlorocarbonyl)amino)-1-methyl-1H-1,2,4-triazol-3-yl)piperazine-1-carboxylate (CAS 1951441-30-7)
- 2-(4-Allyl-5-morpholino-4H-1,2,4-triazol-3-yl)acetonitrile (CAS 328029-73-8)
- Methyl 2-((2-isopropyl-4-(trifluoromethyl)-2H-pyrazolo[3,4-b]pyridin-6-yl)thio)acetate (CAS 1018166-69-2)
- 3-[(5-bromo-1,3,4-thiadiazol-2-yl)oxy]benzonitrile (CAS 1339218-06-2)
- Liraglutide Impurity 25 (CAS CATO-C4X-199225)
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