Voriconazole Impurity 45 CAS 908352-44-3

Description

The occurrence of Voriconazole Impurity 45 is closely related to a nitrile group, fluorine/chlorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Voriconazole Impurity 45 (CAS 908352-44-3), a pharmacopoeial impurity reference standard (molecular formula C6H4Br2ClFN2, MW 318.37 g/mol) used for the identification and quantification of trace impurities in APIs.

Based on its molecular formula C6H4Br2ClFN2, Voriconazole Impurity 45 contains a nitrile group, fluorine/chlorine/bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 318.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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