Doxylamine EP Impurity D CAS 91-02-1
| CAS No. | 91-02-1 |
| Molecular Formula | C12H9NO |
| Molecular Weight | 183.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Doxylamine EP Impurity D (CAS 91-02-1) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9NO and a molecular weight of 183.21 g/mol.
The molecular framework of Doxylamine EP Impurity D (C12H9NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9NO |
| Molecular Weight | 183.21 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Doxylamine Standards
- Doxylamine impurity 25 (CAS 15260-65-8)
- Doxylamine Impurity N91 (CAS CATO-C1460291)
- Doxylamine EP Impurity B (CAS 19490-92-7)
- Doxylamine Hydrogen Succinate EP Impurity B (CAS CATO-C4X-178922)
- Doxylamine Impurity 1 (CAS 100393-43-9)
- Doxylamine impurity 26 (CAS CATO-C4X-178926)
- Doxylamine N,N-DiDesmethyl Impurity (CAS 78868-04-9)
- Doxylamine Impurity 17 (CAS 1221-70-1)
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