Pemetrexed Impurity 42 CAS 912935-56-9
| CAS No. | 912935-56-9 |
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pemetrexed Impurity 42 (C12H14O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Pemetrexed Impurity 42 (CAS 912935-56-9, C12H14O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Pemetrexed Standards
- Pemetrexed Impurity 39 (CAS 89113-43-9)
- Pemetrexed Impurity 10 (CAS 151864-81-2)
- Pemetrexed Impurity (CAS CATO-C4X-172640)
- Pemetrexed Impurity 75 (CAS 240407-05-0)
- Pemetrexed Impurity (CAS 58973-64-1)
- Pemetrexed Impurity 41 (CAS 912935-44-5)
- Pemetrexed Impurity 61 (CAS CATO-C4X-172661)
- Pemetrexed Impurity 53 (CAS 53487-52-8)
Recommended Standards
- Butylphthalide Impurity 21 (CAS 152567-80-1)
- Paliperidone Impurity 46 (CAS 1008796-23-3)
- Butylphthalide Impurity 3 (CAS 550-37-8)
- Paliperidone Impurity 100 (CAS CATO-C4X-1724100)
- Meloxicam impurity 13 (CAS CATO-C4X-169013)
- Icotinib Impurity 6 (CAS 1204313-57-4)
- Bifendate Impurity N2 (CAS 205117-47-1)
- Tert-butyl 2-methoxy-7-oxo-5,7-dihydrospiro[cyclopenta[b]pyridine-6,4'-piperidine]-1'-carboxylate (CAS 2377355-71-8)
- (3,4-Dibromo-3,4,4-trifluorobutanesulfonyl)benzene (CAS 478247-75-5)
- 2-Bromo-N-(tert-butyl)benzamide (CAS 168265-57-4)
- 5-Ethynyl-1,3-dimethyl-1H-pyrazole (CAS 94989-99-8)
- Methyl 3-chloro-2,4-difluorobenzoate (CAS 948833-74-7)
- 3-Chloroquinoxaline-2-carbaldehyde (CAS 49568-68-5)
- Protein Kinase C (19-36) Peptide (CAS 113731-96-7)
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