4'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one CAS 913720-11-3
| CAS No. | 913720-11-3 |
| Molecular Formula | C10H8FNO |
| Molecular Weight | 177.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one (C10H8FNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one (CAS 913720-11-3), molecular formula C10H8FNO and molecular weight 177.18 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8FNO |
| Molecular Weight | 177.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorospiro Standards
- 6'-Fluorospiro[cyclopropane-1,1'-isoindolin]-3'-one (CAS 1440520-01-3)
- 5'-Fluorospiro[cyclopropane-1,1'-isoindolin]-3'-one (CAS 1440520-03-5)
- 5’-Fluorospiro[cyclopropane-1,3’-indolin]-2’-one (CAS 769965-95-9)
- 6'-fluorospiro[cyclopropane-1,3'-indoline]-2'-one (CAS 1378834-16-2)
- 7'-fluorospiro[cyclopropane-1,3'-indoline]-2'-one (CAS 872141-30-5)
- 6'-fluorospiro[azetidine-3,1'-indane] (CAS 1782046-47-2)
- 4'-fluorospiro[azetidine-3,1'-indane] (CAS 1785318-78-6)
- 4'-Fluorospiro[cyclopropane-1,3'-indoline] (CAS 1823904-39-7)
Recommended Standards
- 4-(Allyloxy)-2-fluorobenzonitrile (CAS 448956-54-5)
- 4-Isocyanatobenzo[c][1,2,5]thiadiazole (CAS 342411-14-7)
- 4-(4-Fluorophenyl)-4-oxobutanenitrile (CAS 756489-25-5)
- 5-(2-Fluoro-3-methylphenyl)oxazole (CAS 2007419-40-9)
- 3-Isopropoxy-N-(pyridin-4-ylmethyl)propan-1-amine (CAS 799260-48-3)
- 3,6-Difluoro-2-Methoxybenzyl bromide (CAS 1261645-28-6)
- tert-Butyl 2-methyl-4-(1-(thiazol-2-yl)ethyl)piperazine-1-carboxylate (CAS 1289385-40-5)
- N-[1-(1-methyl-1H-pyrazol-5-yl)-2-oxopiperidin-3-yl]methanesulfonamide (CAS 1803561-50-3)
- 5-Bromo-7-methoxybenzo[d]isoxazole (CAS 198280-98-7)
- 5-[(4-bromophenyl)methyl]-1h-1,2,3,4-tetrazole (CAS 127152-64-1)
- 10-Nitro Oleic Acid (CAS 875685-46-4)
- Methyl 3-((4-isopropylphenoxy)methyl)benzoate (CAS 438464-21-2)
- (R)-5-Bromo-2-methylindoline (CAS 916903-14-5)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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