Ezetimibe Impurity 119 CAS 914777-32-5
| CAS No. | 914777-32-5 |
| Molecular Formula | C11H9FO2 |
| Molecular Weight | 192.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ezetimibe Impurity 119 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Ezetimibe Impurity 119 (CAS 914777-32-5), a pharmacopoeial impurity reference standard (molecular formula C11H9FO2, MW 192.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Ezetimibe Impurity 119 (C11H9FO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H9FO2 |
| Molecular Weight | 192.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Ezetimibe Standards
- Ezetimibe Impurity 112 (CAS CATO-C4X-1098112)
- Ezetimibe Impurity 113 (CAS CATO-C4X-1098113)
- Ezetimibe Impurity 118 (CAS CATO-C4X-1098118)
- Ezetimibe Impurity 111 (CAS CATO-C4X-1098111)
- Ezetimibe Impurity 60 (CAS 538-51-2)
- Ezetimibe Impurity 37 (CAS 149437-76-3)
- Ezetimibe Impurity 73 (CAS 845790-38-7)
- Ezetimibe Impurity 69 (CAS 6744-65-6)
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