Sofosbuvir Impurity 84 CAS 914912-69-9
| CAS No. | 914912-69-9 |
| Molecular Formula | C20H19FO6 |
| Molecular Weight | 374.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sofosbuvir Impurity 84 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Sofosbuvir Impurity 84 (CAS 914912-69-9), a pharmacopoeial impurity reference standard (molecular formula C20H19FO6, MW 374.36 g/mol) used for the identification and quantification of trace impurities in APIs.
Sofosbuvir Impurity 84 (C20H19FO6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19FO6 |
| Molecular Weight | 374.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Sofosbuvir Standards
- Sofosbuvir Impurity 1 (CAS 1033394-94-3)
- Sofosbuvir Impurity 105 (CAS 1946820-91-2)
- Sofosbuvir Impurity 2 (CAS 1157884-58-6)
- Sofosbuvir Impurity 3 (CAS CATO-C4X-10523)
- Sofosbuvir Impurity 46 (CAS 874638-80-9)
- Sofosbuvir Impurity 43 (CAS CATO-C4X-105243)
- Sofosbuvir Impurity 60 (CAS CATO-C4X-105260)
- Sofosbuvir Impurity 80 (CAS CATO-C4X-105280)
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