Venlafaxine Impurity 64 CAS 916918-84-8
| CAS No. | 916918-84-8 |
| Molecular Formula | C24H31NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Venlafaxine Impurity 64 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Venlafaxine Impurity 64 (CAS 916918-84-8, C24H31NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H31NO3HCl, Venlafaxine Impurity 64 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 417.97 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H31NO3 HCl |
| Molecular Weight | 417.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Venlafaxine Standards
- Venlafaxine Impurity 58 (CAS 1000377-27-4)
- Venlafaxine Impurity 31 (CAS 1020719-35-0)
- Venlafaxine Impurity 15 (CAS 1021933-95-8)
- Venlafaxine Impurity 33 (CAS 1062607-49-1)
- Venlafaxine Impurity 36 (CAS 1062609-99-7)
- Venlafaxine EP Impurity G (CAS 1076199-92-2)
- Venlafaxine N-Oxide (CAS 1094598-37-4)
- Venlafaxine Impurity 18 (CAS 1168135-16-7)
Recommended Standards
- Argatroban Impurity 83 (CAS CATO-C4X-100783)
- Tafamidis Impurity 3 (CAS 1183404-30-9)
- Biperiden EP Impurity E (CAS 2832847-11-5)
- 3-Bromo-4-(3-fluorophenoxy)benzene-1-sulfonyl chloride (CAS 1284177-46-3)
- Leptolepisol B (CAS 71332-94-0)
- (3-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)boronic acid (CAS 2225180-89-0)
- 3-Cyclopropyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (CAS 2377607-03-7)
- JNJ-2408068, >98% (HPLC) (CAS 317846-22-3)
- 5-methyl-4-propylthiophene-2-carbohydrazide (CAS 790270-71-2)
- Tau Peptide (301-315) trifluoroacetate salt (CAS 330456-48-9)
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