2,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine CAS 917758-92-0
| CAS No. | 917758-92-0 |
| Molecular Formula | C13H6Cl2FN3 |
| Molecular Weight | 294.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine (C13H6Cl2FN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 2,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine (CAS 917758-92-0), a certified reference material (molecular formula C13H6Cl2FN3, MW 294.11 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H6Cl2FN3 |
| Molecular Weight | 294.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 1-(4-Bromo-3-fluorobenzyl)-3,3-difluoropyrrolidine (CAS 2152775-63-6)
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- 1-(3-Bromo-5-fluorobenzyl)-3,3-difluoropyrrolidine (CAS 1994538-79-2)
- tert-Butyl ((1-(2-aminoacetyl)pyrrolidin-2-yl)methyl)carbamate (CAS 1353944-77-0)
- 5-(2,4-Dichlorophenyl)-1,3,4-thiadiazol-2-amine hydrochloride (CAS 1049735-63-8)
- [(4-methoxyphenyl)(2-oxo-2-{4-[(E)-2-phenylvinyl]piperazin-1-yl}ethyl)amino]acetic (CAS 1142205-54-6)
- 1,1'-Di-n-octyl-4,4'-bipyridinium Dibromide (CAS 36437-30-6)
- Tryptophan impurity 37 (CAS CATO-C4X-137337)
- N-(2,4-difluorophenyl)-2,6-dioxo-1-phenyl-1,2,3,6-tetrahydropyrimidine-4-carboxamide (CAS 861212-14-8)
- 1-(4-(Trifluoromethyl)phenyl)-1H-imidazole (CAS 25371-98-6)
- 7-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine (CAS 2791312-75-7)
- N-(pyridin-3-yl)-1,2,3-thiadiazole-4-carboxamide (CAS 478261-77-7)
- Neuropeptide W-23 (human) (CAS 383415-79-0)
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